2013
Model-based rational feedback controller design for closed-loop deep brain stimulation of Parkinson's disease
Gorzelic P, Schiff S, Sinha A. Model-based rational feedback controller design for closed-loop deep brain stimulation of Parkinson's disease. Journal Of Neural Engineering 2013, 10: 026016. PMID: 23449002, DOI: 10.1088/1741-2560/10/2/026016.Peer-Reviewed Original ResearchConceptsFeedback controller designController designPID controlHigh-level control strategyBetter controller performanceFeedback control methodFeedback control problemController performanceDerivative controlControl methodFeedback controllerControl inputControl lawControl strategyProportional controlOnline estimatesComputational modelControl problemConsiderable further reductionDerivative methodologyOptimal controlAdaptive methodRelay capabilityStimulation algorithmDesign
2012
Modulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel role
1994
Stochastic versus deterministic variability in simple neuronal circuits: I. Monosynaptic spinal cord reflexes
Chang T, Schiff S, Sauer T, Gossard J, Burke R. Stochastic versus deterministic variability in simple neuronal circuits: I. Monosynaptic spinal cord reflexes. Biophysical Journal 1994, 67: 671-683. PMID: 7948680, PMCID: PMC1225409, DOI: 10.1016/s0006-3495(94)80526-0.Peer-Reviewed Original ResearchConceptsTheoretical time seriesEvidence of determinismTime seriesDeterministic equationsNonlinear predictionDeterministic variabilityDeterministic structureSimple neuronal circuitDeterministic behaviorSurrogate dataLocal dispersionStatistical controlLocal flowLong time seriesAutocorrelationEquationsGroup Ia muscle afferentsOscillationsAlgorithmReflex variabilityState
1987
The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra.
Schiff S, Somjen G. The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra. Stroke 1987, 18: 30-37. PMID: 3027927, DOI: 10.1161/01.str.18.1.30.Peer-Reviewed Original ResearchConceptsMild hypoxiaSynaptic transmissionModerate hypoxiaHippocampal slicesGrade of hypoxiaHypoxic brain tissueExtracellular DC potentialDegree of hypoxiaPosthypoxic hyperexcitabilityIschemic penumbraExtracellular calciumExtracellular potassiumSynaptic functionBrain tissueHypoxiaHyperexcitabilityExtracellular pHSlicesSevere depolarizationNeuronsDC potentialResponse
1985
The effects of temperature on synaptic transmission in hippocampal tissue slices
Schiff S, Somjen G. The effects of temperature on synaptic transmission in hippocampal tissue slices. Brain Research 1985, 345: 279-284. PMID: 2994845, DOI: 10.1016/0006-8993(85)91004-2.Peer-Reviewed Original ResearchHyperexcitability following moderate hypoxia in hippocampal tissue slices
Schiff S, Somjen G. Hyperexcitability following moderate hypoxia in hippocampal tissue slices. Brain Research 1985, 337: 337-340. PMID: 2992681, DOI: 10.1016/0006-8993(85)90071-x.Peer-Reviewed Original Research