2023
High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
2022
Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Mukhatayev Z, Bayserkin B, Vermund SH, Ali S. Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan. Scientific Reports 2022, 12: 17195. PMID: 36229577, PMCID: PMC9562405, DOI: 10.1038/s41598-022-22163-7.Peer-Reviewed Original Research
2018
HIV-1 Transmission Clustering and Phylodynamics Highlight the Important Role of Young Men Who Have Sex with Men
Dennis AM, Volz E, Frost A, Hossain M, Poon AFY, Rebeiro P, Vermund SH, Sterling TR, Kalish ML. HIV-1 Transmission Clustering and Phylodynamics Highlight the Important Role of Young Men Who Have Sex with Men. AIDS Research And Human Retroviruses 2018, 34: 879-888. PMID: 30027754, PMCID: PMC6204570, DOI: 10.1089/aid.2018.0039.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCluster AnalysisCross-Sectional StudiesFemaleGenotypeHIV InfectionsHIV-1Homosexuality, MaleHumansMaleMiddle AgedMolecular EpidemiologyPhylogenyPol Gene Products, Human Immunodeficiency VirusRetrospective StudiesRisk FactorsRNA, ViralSequence Analysis, DNATennesseeYoung AdultConceptsYoung MSMTransmission clustersHIV-1 pol sequencesTransmission riskComprehensive Care ClinicHIV transmission patternsVanderbilt Comprehensive Care ClinicYears of ageHIV molecular epidemiologyCross-sectional analysisHigh transmission riskClinical factorsCare clinicsRisk ratioClinical dataImportance of interventionsMSM riskPol sequencesTransmission clusteringYounger ageRisk behaviorsLogistic regressionMolecular epidemiologyMSMYoung men
2015
Genomic Characterization of Two Novel HIV-1 Unique (CRF01_AE/B) Recombinant Forms Among Men Who Have Sex with Men in Beijing, China
Li Z, Li J, Feng Y, Kalish ML, Lu H, Yin L, Liao L, Qian HZ, Frost SD, Ruan Y, Vermund SH, Shao Y, Xing H. Genomic Characterization of Two Novel HIV-1 Unique (CRF01_AE/B) Recombinant Forms Among Men Who Have Sex with Men in Beijing, China. AIDS Research And Human Retroviruses 2015, 31: 921-925. PMID: 26058342, PMCID: PMC4553378, DOI: 10.1089/aid.2015.0076.Peer-Reviewed Original ResearchGenomic Characterization of Two Novel HIV-1 Second-Generation Recombinant Forms Among Men Who Have Sex with Men in Beijing, China
Li Z, Wei H, Feng Y, Li J, Kalish ML, Lu H, Yin L, Liao L, Qian HZ, Frost SD, Ruan Y, Vermund SH, Shao Y, Xing H. Genomic Characterization of Two Novel HIV-1 Second-Generation Recombinant Forms Among Men Who Have Sex with Men in Beijing, China. AIDS Research And Human Retroviruses 2015, 31: 342-346. PMID: 25495675, PMCID: PMC4348344, DOI: 10.1089/aid.2014.0307.Peer-Reviewed Original Research
2014
Current drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report
Qian HZ, Mitchell VJ, Bebawy S, Cassell H, Perez G, McGowan CC, Sterling TR, Vermund SH, D’Aquila R, Hulgan T. Current drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report. BMC Infectious Diseases 2014, 14: 508. PMID: 25234368, PMCID: PMC4175271, DOI: 10.1186/1471-2334-14-508.Peer-Reviewed Original ResearchConceptsUrine drug screensCurrent drug usePositive urine drug screenComputer Assisted Self-InterviewVirologic suppressionDrug useAntiretroviral therapyDrug screensNegative urine drug screensHigher CD4 countsHIV disease progressionRoutine clinic visitsHIV virologic suppressionCross-sectional studyLower self-reported ratesSelf-reported ratesCD4 countClinic visitsPrognostic informationDisease progressionCaucasian raceART usersLower likelihoodResultsAbout halfSelf interview
2011
Antiretroviral Drug Resistance Mutations Among Treated and Treatment-Naive Patients in Pakistan: Diversity of the HIV Type 1 pol Gene in Pakistan
Shah S, Xing H, Altaf A, Chen B, Liao L, Jia Y, Vermund SH, Shao Y. Antiretroviral Drug Resistance Mutations Among Treated and Treatment-Naive Patients in Pakistan: Diversity of the HIV Type 1 pol Gene in Pakistan. AIDS Research And Human Retroviruses 2011, 27: 1277-1282. PMID: 21591988, PMCID: PMC3227241, DOI: 10.1089/aid.2010.0324.Peer-Reviewed Original ResearchConceptsInjection drug usersAntiretroviral drugsDrug resistanceAntiretroviral drug resistance mutationsCalibrated Population Resistance toolHIV-1 subtype A1HIV-1-infected participantsPartial reverse transcriptase regionsARV drug resistanceARV-naive patientsPopulation Resistance toolSpouses of HIVTreatment-naive patientsPrimary drug resistanceHIV-1 subtypesDrug resistance mutationsFemale sex workersReverse transcriptase regionBlood spot cardsNaive patientsHIV patientsDrug adherenceSubtype DARV resistancePredominant subtypeContemporary profile of oral manifestations of HIV/AIDS and associated risk factors in a southeastern US clinic
Tamí‐Maury I, Willig J, Vermund S, Jolly P, Aban I, Hill J, Wilson CM. Contemporary profile of oral manifestations of HIV/AIDS and associated risk factors in a southeastern US clinic. Journal Of Public Health Dentistry 2011, 71: 257-264. PMID: 22320283, DOI: 10.1111/j.1752-7325.2011.00256.x.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsAntiretroviral Therapy, Highly ActiveBlack or African AmericanCandidiasis, OralCD4 Lymphocyte CountCohort StudiesFemaleFollow-Up StudiesHeterosexualityHIV InfectionsHIV-1Homosexuality, MaleHumansMaleMouth DiseasesOropharynxPharyngeal DiseasesPrevalenceRetrospective StudiesRisk FactorsSex FactorsSoutheastern United StatesViral LoadYoung AdultConceptsOral manifestationsOropharyngeal candidiasisRisk factorsUS clinicsHIV-1 RNA viral loadLow baseline CD4 countBaseline CD4 valueMean baseline CD4Active antiretroviral therapyBaseline CD4 countRNA viral loadHIV-positive individualsHIV/AIDSLogistic regression modelsBaseline CD4Antiretroviral therapyCD4 countLaboratory characteristicsRetrospective reviewCD4 valuesViral loadHIV prevalenceMean ageT cellsHAARTAn addition to the effect of treating co-infections on HIV-1 viral load
Modjarrad K, Vermund SH. An addition to the effect of treating co-infections on HIV-1 viral load. The Lancet Infectious Diseases 2011, 11: 81. PMID: 21272789, DOI: 10.1016/s1473-3099(11)70013-5.Peer-Reviewed Original Research
2010
Rethinking Prevention of HIV Type 1 Infection
Burns DN, Dieffenbach CW, Vermund SH. Rethinking Prevention of HIV Type 1 Infection. Clinical Infectious Diseases 2010, 51: 725-731. PMID: 20707698, PMCID: PMC3071685, DOI: 10.1086/655889.Peer-Reviewed Original ResearchEffect of treating co-infections on HIV-1 viral load: a systematic review
Modjarrad K, Vermund SH. Effect of treating co-infections on HIV-1 viral load: a systematic review. The Lancet Infectious Diseases 2010, 10: 455-463. PMID: 20610327, PMCID: PMC3071714, DOI: 10.1016/s1473-3099(10)70093-1.Peer-Reviewed Original ResearchConceptsViral load differencesViral loadPlasma HIV-1 RNA concentrationSystematic reviewMean plasma viral loadPlasma HIV RNA concentrationHIV-1 RNA concentrationsHIV-1 viral loadHIV RNA concentrationPlasma viral loadHIV transmission riskViral load reductionNon-pathogenic infectionsCo-infecting pathogensSyphilis treatmentHIV progressionTuberculosis treatmentEligible studiesPopulation-level benefitsTransmission riskLow-income countriesHIVTreatmentInfectionReviewEstimation of HIV-1 incidence among five focal populations in Dehong, Yunnan: a hard hit area along a major drug trafficking route
Duan S, Shen S, Bulterys M, Jia Y, Yang Y, Xiang L, Tian F, Lu L, Xiao Y, Wang M, Jia M, Jiang H, Vermund SH, Jiang Y. Estimation of HIV-1 incidence among five focal populations in Dehong, Yunnan: a hard hit area along a major drug trafficking route. BMC Public Health 2010, 10: 180. PMID: 20374618, PMCID: PMC2858119, DOI: 10.1186/1471-2458-10-180.Peer-Reviewed Original ResearchConceptsHIV incidenceDiscordant couplesHIV epidemicMajor drug trafficking routesRecent HIV-1 infectionAnnual HIV incidenceHIV-discordant couplesHIV-1 prevalenceHIV-1 incidenceHIV-1 infectionMigration of HIVFemale sex workersPre-marital couplesCross-sectional surveyBED IgGRecent seroconversionIntensive prevention measuresHIV-positivePregnant womenHIV preventionHigh riskResultsFrom 2004Drug usersMultivariate analysisEnzyme immunoassayHuman Immunodeficiency Virus Infection in Alabama Women: Sociodemographic, Behavioral, and Reproductive Health Characteristics and Factors Associated With Lack of Human Immunodeficiency Virus-1 Viral Control
Bhatta MP, Hoesley C, Vermund S. Human Immunodeficiency Virus Infection in Alabama Women: Sociodemographic, Behavioral, and Reproductive Health Characteristics and Factors Associated With Lack of Human Immunodeficiency Virus-1 Viral Control. The American Journal Of The Medical Sciences 2010, 339: 133-140. PMID: 20087169, DOI: 10.1097/maj.0b013e3181c300f9.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBehavioral risk factorsViral controlAlabama womenRisk factorsVirus infectionBlack race/ethnicityT-cell countsCells/microLOutpatient HIV clinicHIV-1 controlReproductive health characteristicsLow viral loadHIV-1 diagnosisBlack womenSelf-administered questionnaireRace/ethnicityAnnual household incomeCervicovaginal lavageAntiretroviral therapyHIV clinicHIV infectionHIV testingSuboptimal access
2009
Willingness to Be Circumcised for Preventing HIV among Chinese Men Who Have Sex with Men
Ruan Y, Qian HZ, Li D, Shi W, Li Q, Liang H, Yang Y, Luo F, Vermund SH, Shao Y. Willingness to Be Circumcised for Preventing HIV among Chinese Men Who Have Sex with Men. AIDS Patient Care And STDs 2009, 23: 315-321. PMID: 19335172, PMCID: PMC2743100, DOI: 10.1089/apc.2008.0199.Peer-Reviewed Original ResearchConceptsClinical trialsChinese MSMChinese menMale circumcisionEffectiveness of circumcisionLack of historyUncircumcised MSMHIV acquisitionHIV/Genital hygieneAdult circumcisionFree medical servicesTight foreskinSide effectsSexual partnersInfection riskMSMCircumcisionPreventing HIVMedical servicesTrialsMenHeterosexual menCommunity educationSexPrevalence of HIV infection and predictors for syphilis infection among female sex workers in southern China.
Lu F, Jia Y, Sun X, Wang L, Liu W, Xiao Y, Zeng G, Li C, Liu J, Cassell H, Chen HT, Vermund SH. Prevalence of HIV infection and predictors for syphilis infection among female sex workers in southern China. The Southeast Asian Journal Of Tropical Medicine And Public Health 2009, 40: 263-72. PMID: 19323011, PMCID: PMC2745968.Peer-Reviewed Original ResearchConceptsFemale sex workersInconsistent condom useSyphilis infectionHIV infectionCondom usePast monthSex workersCross-sectional studyRegular sex partnersVenue-based methodsHalf of participantsEligible participantsRisk factorsSTD symptomsPrevalence ratesDrug usersSex partnersInfectionLess educationPrevalenceMinority ethnic groupsMonthsLiuzhou CityEthnic groupsNon-local residents[Evaluation of BED-CEIA assay with dried blood spot specimens in China].
Shen S, Tian F, Jiang HZ, Sun GQ, Miao LF, Guo XL, Xiao Y, Jia YJ, Vermund SH, Jiang Y. [Evaluation of BED-CEIA assay with dried blood spot specimens in China]. Chinese Journal Of Epidemiology 2009, 30: 273-6. PMID: 19642385.Peer-Reviewed Original ResearchConceptsDBS specimensBED-CEIAHIV-1-positive specimensRecent HIV infectionHIV-1 incidencePositive controlHIV infectionHIV incidenceHIV-positiveVoluntary counselingIncidence rateCutoff valueLow positive controlPositive specimensPlasma specimensWindow periodConcordance rateBlood spotsWestern blotEligible pairsFurther studiesNegative controlDBSIncidenceTesting sites
2008
Impact of small reductions in plasma HIV RNA levels on the risk of heterosexual transmission and disease progression
Modjarrad K, Chamot E, Vermund SH. Impact of small reductions in plasma HIV RNA levels on the risk of heterosexual transmission and disease progression. AIDS 2008, 22: 2179-2185. PMID: 18832881, PMCID: PMC2661869, DOI: 10.1097/qad.0b013e328312c756.Peer-Reviewed Original ResearchConceptsRisk of progressionHeterosexual transmissionDisease progressionHIV RNALog10 incrementAntiretroviral therapyPlasma HIV RNA levelsGreater riskTreatment of coinfectionHIV RNA levelsHIV viral loadViral load changesHIV-1 RNARelative risk estimatesHIV loadAdjunctive careViral loadPlasma levelsHeterosexual contactWorld's HIVAnnual riskHIVAdult populationViral transmissionRisk estimatesEstimates of HIV prevalence in a highly endemic area of China: Dehong Prefecture, Yunnan Province
Jia Y, Sun J, Fan L, Song D, Tian S, Yang Y, Jia M, Lu L, Sun X, Zhang S, Kulczycki A, Vermund SH. Estimates of HIV prevalence in a highly endemic area of China: Dehong Prefecture, Yunnan Province. International Journal Of Epidemiology 2008, 37: 1287-1296. PMID: 18922804, PMCID: PMC2638873, DOI: 10.1093/ije/dyn196.Peer-Reviewed Original ResearchConceptsHIV prevalenceDehong PrefectureCurrent HIV preventionInjection drug useInjection drug usersFemale sex workersHIV/AIDS epidemicHIV/AIDSHIV infectionHIV preventionTreatment challengesClinical dataEndemic areasHIV problemPopulation prevalenceDrug usersDrug usePrevalenceAIDS epidemicWorkbook methodEpidemic patternsSex workersInfectionMillion peopleUneven geographical distribution
2007
Early Infant Human Immunodeficiency Virus Type 1 Detection Suitable for Resource-Limited Settings with Multiple Circulating Subtypes by Use of Nested Three-Monoplex DNA PCR and Dried Blood Spots
Zhang Q, Wang L, Jiang Y, Fang L, Pan P, Gong S, Yao J, Tang YW, Vermund SH, Jia Y. Early Infant Human Immunodeficiency Virus Type 1 Detection Suitable for Resource-Limited Settings with Multiple Circulating Subtypes by Use of Nested Three-Monoplex DNA PCR and Dried Blood Spots. Journal Of Clinical Microbiology 2007, 46: 721-726. PMID: 18077639, PMCID: PMC2238144, DOI: 10.1128/jcm.01539-07.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBloodBlotting, WesternChinaDNA PrimersDNA, ViralEnv Gene Products, Human Immunodeficiency VirusGag Gene Products, Human Immunodeficiency VirusHIV AntibodiesHIV InfectionsHIV-1HumansInfantInfant, NewbornPol Gene Products, Human Immunodeficiency VirusPolymerase Chain ReactionReproducibility of ResultsSensitivity and SpecificitySpecimen HandlingConceptsHIV-1 subtypesMonths of ageDiverse HIV-1 subtypesEarly infant HIV-1 diagnosisHuman immunodeficiency virus type 1 (HIV-1) infectionHIV-1 DNA PCRVirus type 1 infectionDNA PCRType 1 infectionHIV-1 diagnosisDiverse HIV-1Resource limited settingsAntibody enzyme immunoassayBlood spot samplesInfected mothersMaternal antibodiesCRF01-AEDBS specimensEpidemiologic dataHIV-1Deceased infantsInfantsCRF07-BCMultiple subtypesBlood spotsSeroincidence of Recent Human Immunodeficiency Virus Type 1 Infections in China▿
Xiao Y, Jiang Y, Feng J, Xu W, Wang M, Funkhouser E, Vermund SH, Jia Y. Seroincidence of Recent Human Immunodeficiency Virus Type 1 Infections in China▿. MSphere 2007, 14: 1384-1386. PMID: 17671229, PMCID: PMC2168114, DOI: 10.1128/cvi.00356-06.Peer-Reviewed Original Research