2004
Restoration of tumor specific human leukocyte antigens class I-restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer
SANTIN A, BELLONE S, PALMIERI M, BOSSINI B, CANE S, BIGNOTTI E, ROMAN J, CANNON M, PECORELLI S. Restoration of tumor specific human leukocyte antigens class I-restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer. International Journal Of Gynecological Cancer 2004, 14: 64-75. DOI: 10.1111/ijgc-00009577-200401000-00008.Peer-Reviewed Original ResearchCD8+ T cellsAdvanced ovarian cancerPeripheral blood lymphocytesAdvanced ovarian cancer patientsTumor-infiltrating lymphocytesTumor infiltrationOvarian cancer patientsCytotoxic T lymphocytesDendritic cell stimulationOvarian cancerT cellsLymphoblastoid cell linesInfiltrating lymphocytesDendritic cellsKilling of autologous tumor cellsTumor-specific cytotoxic T lymphocytesTumor-specific T-cell responsesAnti-HLA class I mAbCD8+ T cell populationsCancer patientsAutologous ovarian cancer cellsAutologous tumor target cellsCD8+ CTL responsesLevels of CD56 expressionTumor antigen-loaded DC
2001
Phenotypic and Functional Analysis of Tumor-Infiltrating Lymphocytes Compared with Tumor-Associated Lymphocytes from Ascitic Fluid and Peripheral Blood Lymphocytes in Patients with Advanced Ovarian Cancer
Santin AD, Hermonat PL, Ravaggi A, Bellone S, Roman JJ, Smith CV, Pecorelli S, Radominska-Pandya A, Cannon MJ, Parham GP. Phenotypic and Functional Analysis of Tumor-Infiltrating Lymphocytes Compared with Tumor-Associated Lymphocytes from Ascitic Fluid and Peripheral Blood Lymphocytes in Patients with Advanced Ovarian Cancer. Gynecologic And Obstetric Investigation 2001, 51: 254-261. PMID: 11408737, DOI: 10.1159/000058060.Peer-Reviewed Original ResearchConceptsTumor-associated lymphocytesTumor-infiltrating lymphocytesPeripheral blood lymphocytesAdvanced ovarian cancerType 1 cytokinesT cellsBlood lymphocytesOvarian cancerAscitic fluidAntigen-experienced T lymphocytesActivation markers HLA-DREarly activation markers CD25Markers HLA-DRType 2 cytokinesActivation markers CD25Major leukocyte populationsIL-2 pathwayIL-2 receptorFunction of lymphocytesIL-2 productionLow surface expressionLymphocyte subsetsHigher proportionHLA-DRActivation markers