2010
Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds
Nerurkar NL, Sen S, Baker BM, Elliott DM, Mauck RL. Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds. Acta Biomaterialia 2010, 7: 485-491. PMID: 20728589, PMCID: PMC2994961, DOI: 10.1016/j.actbio.2010.08.011.Peer-Reviewed Original ResearchConceptsTissue engineering applicationsElectrospun scaffoldsNanofibrous scaffoldsEngineering applicationsFiber-reinforced soft tissuesDynamic cultureElectrospun nanofibrous scaffoldsCellular ingressSmall pore sizeDynamic culture conditionsMechanical propertiesScaffold thicknessTensile modulusFree-swelling conditionsPore sizeFree-swelling cultureHeterogeneous depositionDense packingInfiltration resultsIngressScaffoldsKnee meniscusApplicationsModulusSoft tissueEngineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement
Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement. Spine 2010, 35: 867-873. PMID: 20354467, PMCID: PMC3421837, DOI: 10.1097/brs.0b013e3181d74414.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBiomechanical PhenomenaCattleCells, CulturedCompressive StrengthExtracellular MatrixFibrocartilageHumansHydrogelsIntervertebral DiscIntervertebral Disc DisplacementMaterials TestingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNanofibersProsthesis DesignSepharoseTissue EngineeringTissue ScaffoldsWeight-Bearing
2009
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus
Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials 2009, 8: 986-992. PMID: 19855383, PMCID: PMC3415301, DOI: 10.1038/nmat2558.Peer-Reviewed Original ResearchConceptsMulti-scale structural hierarchyAnnulus fibrosus tissue engineeringTissue engineering applicationsLoad-bearing tissuesTensile responseEngineering applicationsTissue engineeringLaminatesBiomimetic materialsComplex mechanical functionsNative tissueStructural hierarchySuccessful engineeringEngineeringScaffoldsAnnulus fibrosusGreat interestShearingMechanical functionComplex tissuesDepositionMaterialsReduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics
Boxberger JI, Orlansky AS, Sen S, Elliott DM. Reduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics. Journal Of Biomechanics 2009, 42: 1941-1946. PMID: 19539936, PMCID: PMC2756063, DOI: 10.1016/j.jbiomech.2009.05.008.Peer-Reviewed Original ResearchConceptsDynamic stiffnessCompressive loadEquilibrium loadHigh dynamic stiffnessDynamic loading regimesPhase angleDynamic viscoelastic propertiesMechanical behaviorAxial loadViscoelastic mechanicsOscillatory loadingLoading regimesLow loadViscoelastic propertiesDynamic mechanicsLumbar motion segmentsMechanical mechanismDisc mechanicsStiffnessLoadSpectrum of frequenciesPossible mechanical mechanismsReduced glycosaminoglycansMotion segmentsMechanics
2008
Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc
Beckstein JC, Sen S, Schaer TP, Vresilovic EJ, Elliott DM. Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc. Spine 2008, 33: e166-e173. PMID: 18344845, DOI: 10.1097/brs.0b013e318166e001.Peer-Reviewed Original ResearchAn In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc
Boxberger JI, Auerbach JD, Sen S, Elliott DM. An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc. Spine 2008, 33: 146-154. PMID: 18197098, PMCID: PMC2696404, DOI: 10.1097/brs.0b013e31816054f8.Peer-Reviewed Original ResearchConceptsRange of motionVivo modelDisc degenerationEarly stage disc degenerationRat lumbar intervertebral discsRat lumbar spineDevelopment of therapiesIntervertebral disc degenerationLumbar intervertebral discsHistology 4Glycosaminoglycan contentDisease progressionBACKGROUND DATALumbar spineAnimal modelsAltered biochemistryEarly interventionGlycosaminoglycan levelsGlycosaminoglycan lossPhysiologic levelsDegenerationControl levelsIntervertebral discNucleus pulposusWeeks
2006
Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments
Boxberger JI, Sen S, Yerramalli CS, Elliott DM. Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments. Journal Of Orthopaedic Research® 2006, 24: 1906-1915. PMID: 16865712, DOI: 10.1002/jor.20221.Peer-Reviewed Original Research