2012
Human annulus fibrosus dynamic tensile modulus increases with degeneration
Sen S, Jacobs NT, Boxberger JI, Elliott DM. Human annulus fibrosus dynamic tensile modulus increases with degeneration. Mechanics Of Materials 2012, 44: 93-98. PMID: 22247579, PMCID: PMC3254102, DOI: 10.1016/j.mechmat.2011.07.016.Peer-Reviewed Original ResearchDynamic viscoelastic propertiesViscoelastic propertiesDynamic modulusStrain levelsCyclic loading conditionsCyclic tensile loadingLinear viscoelastic modelHigher dynamic modulusTensile modulus increasesPhase angleHuman annulus fibrosusTensile samplesTensile loadingDecreased phase angleLoading conditionsEffect of degenerationUniaxial tensionAnnulus fibrosusViscoelastic modelEquilibrium strainModulus increases
2011
Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration
O’Connell G, Jacobs NT, Sen S, Vresilovic EJ, Elliott DM. Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration. Journal Of The Mechanical Behavior Of Biomedical Materials 2011, 4: 933-942. PMID: 21783103, PMCID: PMC3143379, DOI: 10.1016/j.jmbbm.2011.02.002.Peer-Reviewed Original Research
2009
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus
Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials 2009, 8: 986-992. PMID: 19855383, PMCID: PMC3415301, DOI: 10.1038/nmat2558.Peer-Reviewed Original ResearchConceptsMulti-scale structural hierarchyAnnulus fibrosus tissue engineeringTissue engineering applicationsLoad-bearing tissuesTensile responseEngineering applicationsTissue engineeringLaminatesBiomimetic materialsComplex mechanical functionsNative tissueStructural hierarchySuccessful engineeringEngineeringScaffoldsAnnulus fibrosusGreat interestShearingMechanical functionComplex tissuesDepositionMaterials
2007
Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs
Baker B, O’Connell G, Sen S, Nathan A, Elliott D, Mauck R. Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs. 2007, 1013-1014. DOI: 10.1115/sbc2007-176434.Peer-Reviewed Original ResearchFunctional tissue engineeringLength scalesLaminate structureCompressive loadingMultiple length scalesTensile deformationTensile propertiesCircumferential tensile propertiesTissue engineeringCentimeter length scalesFiber directionTransverse directionRadial tie fibersMechanical environmentKnee meniscusNanoscale interactionsAdjacent layersStructural propertiesCell patterningMechanical functionHorizontal axisAnnulus fibrosusMeniscusDeformationProperties