2011
Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice
Wang Y, Camirand G, Lin Y, Froicu M, Deng S, Shlomchik WD, Lakkis FG, Rothstein DM. Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice. The Journal Of Immunology 2011, 186: 2809-2818. PMID: 21270412, PMCID: PMC5584652, DOI: 10.4049/jimmunol.0903805.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCell SurvivalGene Knock-In TechniquesHomeostasisIsoantigensLymphocyte ActivationLymphocyte CountLymphocyte DepletionLymphoid TissueMiceMice, Inbred BALB CMice, Inbred C57BLSignal TransductionSirolimusSkin TransplantationT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesConceptsPercent of TregRegulatory T cellsHost disease modelT cellsTolerogenic agentsMammalian targetConversion of TregsEffect of RapaFoxp3(-) T cellsNumber of TregsSolid organ transplantationDisease modelsAlloantigen-induced proliferationWild-type miceRAPA therapyTreg depletionTreg survivalCD4 cellsLymphopenic hostsImmunosuppressive drugsTregsOrgan transplantationAnimal modelsBaseline numberTconv
2003
Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression
Ariyan C, Salvalaggio P, Fecteau S, Deng S, Rogozinski L, Mandelbrot D, Sharpe A, Sayegh MH, Basadonna GP, Rothstein DM. Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression. The Journal Of Immunology 2003, 171: 5673-5677. PMID: 14634073, DOI: 10.4049/jimmunol.171.11.5673.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAdjuvants, ImmunologicAnimalsAntibodies, MonoclonalAntigens, CDAntigens, DifferentiationCTLA-4 AntigenGraft Enhancement, ImmunologicGraft SurvivalImmunoconjugatesInjections, IntraperitonealInjections, IntravenousIslets of Langerhans TransplantationLeukocyte Common AntigensMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutSignal TransductionTransplantation ToleranceUp-RegulationConceptsCTLA-4 expressionCTLA-4Allograft survivalCTLA4-IgAnti-CD45RB therapyIslet allograft survivalCTLA-4 interactionWild-type miceLong-term engraftmentPeripheral toleranceTransplantation toleranceAllogeneic cellsB7-1B7-2Requisite roleEngraftmentMiceB7SurvivalSpecific roleCritical roleExpressionTransplantationTherapyRecipients
2001
Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models
Rothstein D, Livak M, Kishimoto K, Ariyan C, Qian H, Fecteau S, Sho M, Deng S, Zheng X, Sayegh M, Basadonna G. Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models. The Journal Of Immunology 2001, 166: 322-329. PMID: 11123308, DOI: 10.4049/jimmunol.166.1.322.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntibodies, BlockingAntibodies, MonoclonalB-LymphocytesCD40 LigandCD8-Positive T-LymphocytesCell MovementCytokinesDrug Therapy, CombinationGraft SurvivalIslets of Langerhans TransplantationLeukocyte Common AntigensMaleMiceMice, Inbred BALB CMice, Inbred C57BLModels, ImmunologicalMonocytesProtein IsoformsSignal TransductionSkin TransplantationTransplantation ToleranceConceptsCostimulatory blockadeCD40 ligand blockadeStringent transplant modelSkin allograft survivalBlockade of CD28Induction of toleranceTh2 cytokine expressionLong-term engraftmentImmunogenic allograftAllograft survivalAllograft toleranceAllograft rejectionC57BL/6 recipientsCD8 cellsIslet allograftsTh1 cytokinesTransplant modelCostimulatory pathwayCytokine expressionCD40 ligandMurine modelB cellsTerm engraftmentBlockadeEngraftment