2010
Polarized Secretion of Drosophila EGFR Ligand from Photoreceptor Neurons Is Controlled by ER Localization of the Ligand-Processing Machinery
Yogev S, Schejter ED, Shilo BZ. Polarized Secretion of Drosophila EGFR Ligand from Photoreceptor Neurons Is Controlled by ER Localization of the Ligand-Processing Machinery. PLOS Biology 2010, 8: e1000505. PMID: 20957186, PMCID: PMC2950126, DOI: 10.1371/journal.pbio.1000505.Peer-Reviewed Original ResearchConceptsRhomboid 3Photoreceptor neuronsEndoplasmic reticulum localizationAxonal terminiDrosophila visual systemRhomboid proteasesLigand SpitzTrafficking stepsER localizationSubcellular localizationPolarized secretionEGFR ligandsPhotoreceptor axonsCell bodiesTerminusLocalizationNeuronal cell bodiesSecretionTraffickingMachineryProteinERNeuronsProteaseAxons
2008
Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases
Yogev S, Schejter ED, Shilo B. Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases. The EMBO Journal 2008, 27: 1219-1230. PMID: 18369317, PMCID: PMC2367402, DOI: 10.1038/emboj.2008.58.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CompartmentationCell LineDrosophila melanogasterDrosophila ProteinsEndoplasmic ReticulumEpidermal Growth FactorErbB ReceptorsEye ProteinsGerm CellsHydrolysisIntracellular MembranesMembrane ProteinsProtein KinasesReceptors, Invertebrate PeptideRho GTP-Binding ProteinsSerine EndopeptidasesSignal TransductionConceptsLate compartmentsRho proteinsDifferential compartmentalizationEGFR activationRhomboid intramembrane proteasesEGF receptor activationAmount of chaperoneEGF receptor ligandsIntramembrane proteasesDrosophila EGFRSecretory pathwayGerm lineCompartment localizationSubsequent secretionProteinCompartmentalizationReceptor activationRho 3CompartmentsActivationChaperonesERProteasePathwayReceptor ligands