2024
A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
Ricard J, Labache L, Segal A, Dhamala E, Cocuzza C, Jones G, Yip S, Chopra S, Holmes A. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Communications Biology 2024, 7: 1178. PMID: 39300138, PMCID: PMC11413242, DOI: 10.1038/s42003-024-06836-9.Peer-Reviewed Original ResearchConceptsCocaine use disorderPatterns of functional connectivityUse disorderFunctional connectivityReceptor densityLarge-scale functional brain networksMaintenance of substance useDopamine D2/3 receptorsDopamine receptor densityCortico-striatal circuitsProfile of functional connectivitySubstance use disordersFunctional brain networksNeurotransmitter receptor densityD2/3 receptorsDopamine systemTransporter bindingSubcortical systemsBrain networksSubstance useCocaineSpatial topographyDisordersDopamineBiological mechanisms
2021
Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants
Lichenstein SD, Manco N, Cope LM, Egbo L, Garrison KA, Hardee J, Hillmer AT, Reeder K, Stern EF, Worhunsky P, Yip SW. Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants. Neuropsychopharmacology 2021, 47: 1000-1028. PMID: 34839363, PMCID: PMC8938408, DOI: 10.1038/s41386-021-01226-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdolescent cannabis usersCannabis-related harmsCannabis usersCannabis effectsAdolescent brain functionOngoing brain developmentFunctional neuroimaging studiesEffects of cannabisAdolescent brainNeuroimaging studiesNeural effectsPotential moderatorsNeural alterationsCannabis policy changesReduced perceptionSystematic reviewCannabis useCerebellar regionsAdolescenceBrain functionPreliminary evidenceFuture researchEarly interventionLong-term goalExtant literature
2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamineConnectome-Based Prediction of Cocaine Abstinence
Yip SW, Scheinost D, Potenza MN, Carroll KM. Connectome-Based Prediction of Cocaine Abstinence. American Journal Of Psychiatry 2019, 176: 156-164. PMID: 30606049, PMCID: PMC6481181, DOI: 10.1176/appi.ajp.2018.17101147.Peer-Reviewed Original ResearchMeSH KeywordsAdultBehavior TherapyBrainCholinesterase InhibitorsCocaine-Related DisordersCognitionConnectomeExecutive FunctionFemaleFunctional NeuroimagingGalantamineHumansIndividualityMachine LearningMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysOpiate Substitution TreatmentOpioid-Related DisordersPrognosisRewardTreatment OutcomeConceptsConnectome-based predictive modelingCocaine use disorderUse disordersBrain-based predictorsLarge-scale neural networksFunctional MRI dataCocaine abstinenceExecutive controlReward responsivenessIndividual differencesBaseline cocaine usePosttreatment assessmentConnectivity strengthHeterogeneous sampleAbstinenceIndependent samplesNovel interventionsCanonical networksSpecific behaviorsCocaine useSignificant correspondenceDisordersTreatment outcomesNetwork strengthMRI data
2018
Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder
Carroll KM, Nich C, Frankforter TL, Yip SW, Kiluk BD, DeVito EE, Sofuoglu M. Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder. Drug And Alcohol Dependence 2018, 192: 264-270. PMID: 30300800, PMCID: PMC6203294, DOI: 10.1016/j.drugalcdep.2018.08.019.Peer-Reviewed Original ResearchConceptsOpioid use disorderOral naltrexoneUse disordersAffective symptomsVoucher-based contingency managementDysphoric symptomsAffective distressOral naltrexone treatmentMultiple baseline characteristicsBaseline characteristicsNaltrexone treatmentHigh riskNaltrexoneSomatic symptomsSymptomsContingency managementTreatmentHigh rateDistressSubstantial evidenceTrialsTheoretical benefitsDisordersAffective discomfortParticipants
2017
Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder
Yip SW, Gross JJ, Chawla M, Ma SS, Shi XH, Liu L, Yao YW, Zhu L, Worhunsky PD, Zhang J. Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder. Neuropsychopharmacology 2017, 43: 1364-1372. PMID: 29154365, PMCID: PMC5916358, DOI: 10.1038/npp.2017.283.Peer-Reviewed Original ResearchConceptsDrug-naïve youthNeural processingEmotion regulationNegative affectGaming disorderGroup differencesEmotion regulation taskNegative affective cuesNegative affective stimuliLateral prefrontal cortexInternet gaming disorderAffective cuesAffective stimuliNegative stimuliFMRI scanningIndependent component analysisTask performanceMixed-effects ANOVASubstance use disordersNeural responsesRegulation taskAddictive behaviorsBehavioral addictionsPrefrontal cortexDrugs of abuseGray‐matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions
Yip SW, Worhunsky PD, Xu J, Morie KP, Constable RT, Malison RT, Carroll KM, Potenza MN. Gray‐matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions. Addiction Biology 2017, 23: 394-402. PMID: 28150390, PMCID: PMC5538947, DOI: 10.1111/adb.12492.Peer-Reviewed Original Research
2016
Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2014
Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1. Drug And Alcohol Dependence 2014, 140: 33-41. PMID: 24793365, PMCID: PMC4057888, DOI: 10.1016/j.drugalcdep.2014.03.031.Peer-Reviewed Original ResearchConceptsCannabis-dependent participantsMagnetic resonance imagingCannabis dependenceHC participantsTreatment responseConsecutive abstinenceHealthy comparison menBilateral putamen volumesCannabis-dependent individualsSuccessful treatment outcomeEfficacy of therapeuticsDays of abstinenceVentral striatal activationClinical trialsStriatal functionTreatment outcomesMRI scanningComparison menPutamen volumeResonance imagingBehavioral treatmentBiological markersBrain functionBrain structuresAbstinence
2011
Reduced genual corpus callosal white matter integrity in pathological gambling and its relationship to alcohol abuse or dependence
Yip SW, Lacadie C, Xu J, Worhunsky PD, Fulbright RK, Constable RT, Potenza MN. Reduced genual corpus callosal white matter integrity in pathological gambling and its relationship to alcohol abuse or dependence. The World Journal Of Biological Psychiatry 2011, 14: 129-138. PMID: 21545245, PMCID: PMC3689213, DOI: 10.3109/15622975.2011.568068.Peer-Reviewed Original Research
2009
Risk/reward decision-making in schizophrenia: A preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance
Yip SW, Sacco KA, George TP, Potenza MN. Risk/reward decision-making in schizophrenia: A preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance. Schizophrenia Research 2009, 110: 156-164. PMID: 19269138, PMCID: PMC2817985, DOI: 10.1016/j.schres.2009.01.012.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TaskIowa Gambling TaskTask performanceCard Sorting TaskSchizophrenia show deficitsRisk/rewardNon-psychiatric controlsNeurocognitive tasksGambling TaskCognitive functioningIGT performanceSorting TaskWCST performanceComputerized versionRisk/TaskSchizophreniaDeficitsMixed resultsSubject groupsPreliminary examinationIndividualsClinical factorsFurther researchTobacco smoking