2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2021
Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factorsPatterns of recommended vaccine receipt among women ages 24–45 years: a cross-sectional analysis
Ellingson MK, Oliveira CR, Sheth SS, Sullivan EL, Torres A, Shapiro ED, Niccolai LM. Patterns of recommended vaccine receipt among women ages 24–45 years: a cross-sectional analysis. BMC Public Health 2021, 21: 1283. PMID: 34193100, PMCID: PMC8247221, DOI: 10.1186/s12889-021-11340-4.Peer-Reviewed Original ResearchConceptsMid-adult womenVaccine receiptCross-sectional analysisHPV vaccineOngoing case-control studyReceipt of influenzaHealth care visitsCase-control studyWomen ages 24Quarter of adultsLogistic regression analysisCare visitsIndividual vaccinesHealthcare utilizationMultiple vaccinesVaccineAge 24White womenWomenDemographic characteristicsRegression analysisLower ratesInfluenzaReceiptPast yearAssociation of Inadvertent 9-Valent Human Papillomavirus Vaccine in Pregnancy With Spontaneous Abortion and Adverse Birth Outcomes
Kharbanda EO, Vazquez-Benitez G, DeSilva MB, Naleway AL, Klein NP, Hechter RC, Glanz JM, Donahue JG, Jackson LA, Sheth SS, Greenberg V, Panagiotakopoulos L, Mba-Jonas A, Lipkind HS. Association of Inadvertent 9-Valent Human Papillomavirus Vaccine in Pregnancy With Spontaneous Abortion and Adverse Birth Outcomes. JAMA Network Open 2021, 4: e214340. PMID: 33818618, PMCID: PMC8022219, DOI: 10.1001/jamanetworkopen.2021.4340.Peer-Reviewed Original ResearchConceptsVaccine exposureHuman papillomavirus vaccineAdverse birth outcomesBirth outcomesSGA birthLive birthsPapillomavirus vaccinePreterm birthSpontaneous abortionCox proportional hazards regression modelProportional hazards regression modelsVaccine Safety DatalinkMean maternal ageMedical record reviewAge 45 yearsTime of pregnancyHazards regression modelsBirth defectsMajor structural birth defectsAge 26 yearsElectronic health recordsCohort studySingleton pregnanciesFinal cohortRecord reviewInpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women
Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Inpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women. Women's Health Issues 2021, 31: 384-391. PMID: 33715924, PMCID: PMC8260440, DOI: 10.1016/j.whi.2021.02.002.Peer-Reviewed Original ResearchConceptsHPV vaccinePostpartum womenPatient-centered approachHPV immunization programHuman papillomavirus vaccineRates of immunizationIterative thematic approachYoung adult femalesInpatient immunizationHospital dischargePapillomavirus vaccinePostpartum patientsMedian ageImmunization programsPatient's perspectiveProgram implementationVaccine hesitancyImmunizationVaccineWomenQualitative studyThematic approachPatientsHospitalAdult females
2020
Evaluation of an Inpatient Postpartum Human Papillomavirus Immunization Program.
Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Evaluation of an Inpatient Postpartum Human Papillomavirus Immunization Program. Obstetrics And Gynecology 2020, 136: 1006-1015. PMID: 33030866, PMCID: PMC7584732, DOI: 10.1097/aog.0000000000004097.Peer-Reviewed Original ResearchConceptsHPV immunization programImmunization programsHPV vaccinePostpartum womenHuman papillomavirus immunization programmesLow-income patient populationCharacteristics of patientsRates of immunizationHospital-based obstetricsProportion of womenChi-squared testEligible visitsOutpatient doseOutpatient dosesHospital stayVaccine seriesCohort studyHospital dischargeGynecology clinicVaccine uptakePatient populationAdditional dosesSubsequent doseLogistic regressionDose
2019
Compliance with cervical cancer screening guidelines in young female patients: rates and trends of screening in New Haven County, CT
Oliveira CR, Hosier H, Pate B, Niccolai LM, Sheth SS, Vash-Margita A. Compliance with cervical cancer screening guidelines in young female patients: rates and trends of screening in New Haven County, CT. American Journal Of Obstetrics And Gynecology 2019, 221: 530-532. PMID: 31279847, PMCID: PMC6829042, DOI: 10.1016/j.ajog.2019.07.002.Peer-Reviewed Original Research
2018
Risk of Spontaneous Abortion After Inadvertent Human Papillomavirus Vaccination in Pregnancy
Kharbanda EO, Vazquez-Benitez G, Lipkind HS, Sheth SS, Zhu J, Naleway AL, Klein NP, Hechter R, Daley MF, Donahue JG, Jackson ML, Kawai AT, Sukumaran L, Nordin JD. Risk of Spontaneous Abortion After Inadvertent Human Papillomavirus Vaccination in Pregnancy. Obstetrics And Gynecology 2018, 132: 35-44. PMID: 29889760, PMCID: PMC6019196, DOI: 10.1097/aog.0000000000002694.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdolescentAdultChildDatabases, FactualFemaleHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18HumansMaternal ExposurePapillomaviridaePapillomavirus InfectionsPregnancyProportional Hazards ModelsRetrospective StudiesRisk FactorsStillbirthTime FactorsVaccinationYoung AdultConceptsHuman papillomavirus vaccinationSpontaneous abortionSpontaneous abortion riskPapillomavirus vaccinationCox modelAbortion riskQuadrivalent human papillomavirus vaccinationTime-dependent covariate Cox modelRetrospective observational cohortVaccine Safety DatalinkWeeks of gestationYears of agePregnancy exposureChart reviewMultiple gestationsObservational cohortWomen 12Mean agePregnancy endStandard Cox modelLive birthsPregnancyExposure windowsVaccinationHealth system
2017
Missed opportunities for HPV immunization among young adult women
Oliveira CR, Rock RM, Shapiro ED, Xu X, Lundsberg L, Zhang LB, Gariepy A, Illuzzi JL, Sheth SS. Missed opportunities for HPV immunization among young adult women. American Journal Of Obstetrics And Gynecology 2017, 218: 326.e1-326.e7. PMID: 29223597, PMCID: PMC5924702, DOI: 10.1016/j.ajog.2017.11.602.Peer-Reviewed Original ResearchConceptsHuman papillomavirus immunizationYoung adult womenGynecology clinicAdult womenMissed clinical opportunitiesVaccine-eligible visitsVaccine-eligible womenHuman papillomavirus vaccineMultivariable logistic regressionCross-sectional studyHospital-based obstetricsYears of ageYoung adult populationSignificant racial disparitiesUrban obstetricsPostpartum visitClinic visitsEligible womenPapillomavirus vaccinePatient characteristicsHPV immunizationHuman papillomavirusAdjusted oddsMedical recordsDifferent vaccines
2015
Wide Variation Found In Hospital Facility Costs For Maternity Stays Involving Low-Risk Childbirth
Xu X, Gariepy A, Lundsberg LS, Sheth SS, Pettker CM, Krumholz HM, Illuzzi JL. Wide Variation Found In Hospital Facility Costs For Maternity Stays Involving Low-Risk Childbirth. Health Affairs 2015, 34: 1212-1219. PMID: 26153317, DOI: 10.1377/hlthaff.2014.1088.Peer-Reviewed Original ResearchConceptsCesarean deliveryHospital costsMaternity staysSerious maternal morbidityNationwide Inpatient SampleCoordination of careValue of careMaternal morbidityHospital admissionInpatient SampleDelivery system reformRural hospitalsUS hospitalsHospital practiceSafe reductionHospitalChildbirthStayLong stayHigh rateCareLower proportionUnited StatesFacility costs
2014
Patient and provider perspectives on Bedsider.org, an online contraceptive information tool, in a low income, racially diverse clinic population
Gressel GM, Lundsberg LS, Illuzzi JL, Danton CM, Sheth SS, Xu X, Gariepy A. Patient and provider perspectives on Bedsider.org, an online contraceptive information tool, in a low income, racially diverse clinic population. Contraception 2014, 90: 588-593. PMID: 25139723, DOI: 10.1016/j.contraception.2014.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultContraceptionContraception BehaviorCounselingFamily Planning ServicesFemaleFocus GroupsHealth Knowledge, Attitudes, PracticeHealth PersonnelHumansInformation Seeking BehaviorInternetPatient Education as TopicPerceptionPovertyPregnancyUnited StatesWomen's HealthYoung AdultConceptsClinic providersPatient participantsDiverse clinic populationProvider perspectivesHealth careUrban clinic settingWomen ages 18Women's health careProviders/staffNew contraceptive methodsStructured interview guideUrban MedicaidUrban clinicClinic populationActive womenClinic settingUnplanned pregnancyContraceptive methodsPatientsProviders' understandingContraceptive educationAge 18Contraceptive toolAmerican CongressClinic