2007
Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress
Payabvash S, Kiumehr S, Nezami BG, Zandieh A, Anvari P, Tavangar SM, Dehpour AR. Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress. Liver International 2007, 27: 538-547. PMID: 17403194, DOI: 10.1111/j.1478-3231.2007.01457.x.Peer-Reviewed Original ResearchConceptsAnti-oxidant balanceBile duct ligationChronic cholestasisEndogenous opioidsCholestatic ratsHepatocyte apoptosisOpioid antagonistRat modelHepatic lipid peroxidation levelsSerum liver enzymesCholestatic liver diseaseEndogenous opioid systemHepatic glutathione levelsAnti-oxidant defensesLipid peroxidation levelsAnti-oxidant enzyme activitiesChronic treatmentNaltrexone treatmentCholestatic animalsLiver diseaseBDL ratsHepatic damageDuct ligationLiver enzymesCholestasis
2006
Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver
Payabvash S, Beheshtian A, Salmasi AH, Kiumehr S, Ghahremani MH, Tavangar SM, Sabzevari O, Dehpour AR. Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver. Life Sciences 2006, 79: 972-980. PMID: 16750225, DOI: 10.1016/j.lfs.2006.05.008.Peer-Reviewed Original ResearchConceptsChronic morphine treatmentMorphine treatmentMorphine administrationHigh dosesInduction of apoptosisInduction of liverHepatic glutathione concentrationAntioxidant defenseLiver antioxidant defensesObserved adverse effectsPro-oxidant effectsCancer painEnzymatic antioxidant defensesOpioid analgesicsChronic painOpioid drugsTumor spreadOpioid receptorsSame dosesHepatotoxic effectsProtective roleTumor growthLow dosesMorphineHepatocyte apoptosisNaltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats
Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, Shariftabrizi A, Tavangar SM, Moezi L, Payabvash S, Karoon A, Hoseininik H, Mann DA, Moore KP, Mani AR, Dehpour AR. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut 2006, 55: 1606. PMID: 16543289, PMCID: PMC1860108, DOI: 10.1136/gut.2005.076778.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsProcollagen I expressionHepatic fibrosisBile ductSelective delta-opioid receptor agonistI expressionDelta-opioid receptor agonistAlpha-smooth muscle actinCultured hepatic stellate cellsOpioid receptor antagonistHepatic hydroxyproline levelsEffects of naltrexoneOpioid receptor agonistsHepatic GSH/GSSG ratioReverse transcriptase-polymerase chain reactionTIMP-1 expressionRat hepatic stellate cellsMMP-2 activityTranscriptase-polymerase chain reactionSmooth muscle actinMatrix metalloproteinase-2GSH/GSSG ratioDelta1 receptorsActivated Rat Hepatic Stellate CellsBiliary cirrhosis