2010
Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer
Cheng Y, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International Journal Of Cancer 2010, 127: 568-577. PMID: 19957330, PMCID: PMC3270092, DOI: 10.1002/ijc.25086.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor 2IGF2 LOIColorectal cancerLoss of imprintingPrimary colorectal cancerIGF2 expressionNormal colorectal tissuesPrimary CRC tumorsSignificant correlationGrowth factor 2CRC tumorigenesisCRC tumorsIGF2 levelsColorectal tissuesIGF2 overexpressionH19 methylationHuman malignanciesMicrosatellite instabilityExpression correlatesNormal tissuesH19 hypomethylationCancerCommon eventAberrant gene expressionFactor 2
2008
CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer
Cheng YW, Pincas H, Bacolod MD, Schemmann G, Giardina SF, Huang J, Barral S, Idrees K, Khan SA, Zeng Z, Rosenberg S, Notterman DA, Ott J, Paty P, Barany F. CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer. Clinical Cancer Research 2008, 14: 6005-6013. PMID: 18829479, PMCID: PMC3268558, DOI: 10.1158/1078-0432.ccr-08-0216.Peer-Reviewed Original ResearchConceptsCpG island methylator phenotypeColorectal cancerChromosomal aberrationsLigase detection reactionMicrosatellite instabilityRight-side colonPrimary colorectal cancerColorectal cancer developmentSporadic colorectal cancerSame study cohortCIMP-positive tumorsChromosomal instabilityStudy cohortAberrant promoter methylationPrimary tumorNormal mucosaBRAF mutationsIndependent markerPhenotype associatesDegree of aneuploidyBRAF mutation V600ETumor progressionIndependent molecular mechanismsCancerCancer development