2023
Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis
Morris M, Jain A, Sun B, Kurbatov V, Muca E, Zeng Z, Jin Y, Roper J, Lu J, Paty P, Johnson C, Khan S. Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis. Cancer Letters 2023, 574: 216384. PMID: 37716465, PMCID: PMC10620771, DOI: 10.1016/j.canlet.2023.216384.Peer-Reviewed Original ResearchConceptsLiver metastasesColon cancer liver metastasisCancer liver metastasesSided colon cancerSubset of patientsGrowth factor betaMulti-omics analysisFatty acid oxidationMetastatic diseaseInferior survivalClinical differencesClinical behaviorUntargeted metabolomics analysisTumor behaviorColon cancerBile acidsTumor cell metabolismFactor betaPatientsMetastasisPI3K-AktReactive oxygen speciesMEK-ERKLiquid chromatography-mass spectrometryRCC
2017
Prognostic signatures of oligometastasis in colorectal cancer liver metastasis.
Khan S, Paty P, Zeng Z, Lu J. Prognostic signatures of oligometastasis in colorectal cancer liver metastasis. Journal Of Clinical Oncology 2017, 35: 3588-3588. DOI: 10.1200/jco.2017.35.15_suppl.3588.Peer-Reviewed Original ResearchColorectal cancer liver metastasesCancer liver metastasesHox gene familyLiver metastasesGene familyLonger recurrence-free survivalUnique molecular subtypePrimary colorectal cancerRecurrence-free survivalSelection of patientsRisk of recurrenceUseful prognostic informationFrozen tumor tissueCRCLM patientsOligometastatic phenotypeMetastasis resectionFree survivalLimited metastasesLiver resectionOverall survivalClinical outcomesWidespread metastasesFurther mechanistic studiesColorectal cancerHOX family members