2006
Human Neutrophil Calprotectin Reduces the Susceptibility of Borrelia burgdorferi to Penicillin
Montgomery RR, Schreck K, Wang X, Malawista SE. Human Neutrophil Calprotectin Reduces the Susceptibility of Borrelia burgdorferi to Penicillin. Infection And Immunity 2006, 74: 2468-2472. PMID: 16552081, PMCID: PMC1418918, DOI: 10.1128/iai.74.4.2468-2472.2006.Peer-Reviewed Original ResearchConceptsClearance of spirochetesB. burgdorferiSites of inflammationTherapeutic dosesCalprotectinGrowth of spirochetesLeukocyte componentsNeutrophil calprotectinAntibiotic sensitivitySpirochetal agentLyme diseaseTherapeutic antibioticsBorrelia burgdorferiPenicillin GProtein calprotectinInflammationBurgdorferiSpirochetesDiseaseDoxycyclineDosesClearance
2003
Calprotectin, an Abundant Cytosolic Protein from Human Polymorphonuclear Leukocytes, Inhibits the Growth of Borrelia burgdorferi
Lusitani D, Malawista SE, Montgomery RR. Calprotectin, an Abundant Cytosolic Protein from Human Polymorphonuclear Leukocytes, Inhibits the Growth of Borrelia burgdorferi. Infection And Immunity 2003, 71: 4711-4716. PMID: 12874352, PMCID: PMC166021, DOI: 10.1128/iai.71.8.4711-4716.2003.Peer-Reviewed Original ResearchConceptsPolymorphonuclear leukocytesB. burgdorferiGranule-poor cytoplastsBorrelia burgdorferiBlood polymorphonuclear leukocytesHuman blood polymorphonuclear leukocytesNumerous polymorphonuclear leukocytesPotent bacteriostatic agentHuman polymorphonuclear leukocytesU-CytAcute inflammationCalprotectinModulatory roleLyme spirocheteLyme diseaseSpecific antibodiesProtein calprotectinBurgdorferiLeukocytesAbundant cytosolic proteinOxidative mechanismsBacteriostatic agentRegrowth assaysQuantitative microscopicInflammation