2017
CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation
Kuwahara G, Hashimoto T, Tsuneki M, Yamamoto K, Assi R, Foster TR, Hanisch JJ, Bai H, Hu H, Protack CD, Hall MR, Schardt JS, Jay SM, Madri JA, Kodama S, Dardik A. CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1147-1156. PMID: 28450292, PMCID: PMC5467640, DOI: 10.1161/atvbaha.117.309385.Peer-Reviewed Original ResearchConceptsExtracellular matrix depositionKnockout miceExtracellular matrix componentsExtracellular matrix productionMatrix depositionAdhesion molecule-1 expressionM2 macrophagesProtein 1Matrix productionCell adhesion molecule-1 expressionMolecule-1 expressionProtein expressionMatrix componentsCD44 knockout miceProtein-1 expressionMajor receptorCD44 activityMaturationVascular cell adhesion molecule-1 expressionAdhesion moleculesExpressionCD44 mRNAChemoattractant protein-1 expressionWild-type C57BL/6JArteriovenous fistula
2015
Disturbed shear stress reduces Klf2 expression in arterial‐venous fistulae in vivo
Yamamoto K, Protack CD, Kuwahara G, Tsuneki M, Hashimoto T, Hall MR, Assi R, Brownson KE, Foster TR, Bai H, Wang M, Madri JA, Dardik A. Disturbed shear stress reduces Klf2 expression in arterial‐venous fistulae in vivo. Physiological Reports 2015, 3: e12348. PMID: 25780089, PMCID: PMC4393175, DOI: 10.14814/phy2.12348.Peer-Reviewed Original ResearchArteriovenous fistulaKLF2 expressionDisturbed shear stressFistula diameterMouse aortocaval fistula modelArterial-venous fistulaProtein expressionAortocaval fistula modelInferior vena cavaPotential therapeutic targetAVF maturationAVF patencyDuplex ultrasoundArterial inflowVena cavaVenous outflowArterial limbVenous limbFistula modelMouse modelArterial samplesFistulaTherapeutic targetWestern blotGauge needle
2014
Vein graft adaptation and fistula maturation in the arterial environment
Lu DY, Chen EY, Wong DJ, Yamamoto K, Protack CD, Williams WT, Assi R, Hall MR, Sadaghianloo N, Dardik A. Vein graft adaptation and fistula maturation in the arterial environment. Journal Of Surgical Research 2014, 188: 162-173. PMID: 24582063, PMCID: PMC3972303, DOI: 10.1016/j.jss.2014.01.042.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaVein graftsVein graft adaptationVenous adaptationGraft adaptationArterial environmentCommon surgical procedureAVF maturationDifferent hemodynamic conditionsFistula maturationVenous dilationUnderlying molecular mechanismsIntimal thickeningSurgical proceduresWall thickeningHemodynamic conditions
2013
The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation
Yamamoto K, Protack CD, Tsuneki M, Hall MR, Wong DJ, Lu DY, Assi R, Williams WT, Sadaghianloo N, Bai H, Miyata T, Madri JA, Dardik A. The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation. AJP Heart And Circulatory Physiology 2013, 305: h1718-h1725. PMID: 24097429, PMCID: PMC3882542, DOI: 10.1152/ajpheart.00590.2013.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaMaturation failureHigh-resolution Doppler ultrasoundArteriovenous fistula maturationFirst animal modelMature arteriovenous fistulaSmooth muscle cellsHuman AVF maturationAVF maturationAortocaval fistulaAVF failureFistula maturationImmediate thrombosisVenous adaptationExcellent patencyDoppler ultrasoundAnimal modelsDay 21Human patientsNeedle punctureDay 42Muscle cellsFistulaArterial environmentFailure