2013
A two-year longitudinal pilot MRI study of the brainstem in autism
Jou RJ, Frazier TW, Keshavan MS, Minshew NJ, Hardan AY. A two-year longitudinal pilot MRI study of the brainstem in autism. Behavioural Brain Research 2013, 251: 163-167. PMID: 23619132, PMCID: PMC4107420, DOI: 10.1016/j.bbr.2013.04.021.Peer-Reviewed Original ResearchConceptsBrainstem volumeMRI studiesLongitudinal MRI studyPilot MRI studyTotal brain volumeBrain growth trajectoriesAge 15 yearsGray matter volumeAtypical growth patternGray matter structuresBrainstem abnormalitiesSignificant group differencesPathobiology of autismBrainstem developmentBilateral increaseMRI volumetrySensory abnormalitiesClinical significanceMatter volumeBrain volumeControl groupStructural MRIBrainstemPilot studyNeurodevelopmental disorders
2011
Structural Neural Phenotype of Autism: Preliminary Evidence from a Diffusion Tensor Imaging Study Using Tract-Based Spatial Statistics
Jou RJ, Mateljevic N, Kaiser MD, Sugrue DR, Volkmar FR, Pelphrey KA. Structural Neural Phenotype of Autism: Preliminary Evidence from a Diffusion Tensor Imaging Study Using Tract-Based Spatial Statistics. American Journal Of Neuroradiology 2011, 32: 1607-1613. PMID: 21799040, PMCID: PMC7965377, DOI: 10.3174/ajnr.a2558.Peer-Reviewed Original ResearchDiffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity
Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR. Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity. Australian & New Zealand Journal Of Psychiatry 2011, 45: 153-162. PMID: 21128874, PMCID: PMC3123660, DOI: 10.3109/00048674.2010.534069.Peer-Reviewed Original Research
2010
Reduced central white matter volume in autism: Implications for long‐range connectivity
Jou RJ, Mateljevic N, Minshew NJ, Keshavan MS, Hardan AY. Reduced central white matter volume in autism: Implications for long‐range connectivity. Psychiatry And Clinical Neurosciences 2010, 65: 98-101. PMID: 21265943, PMCID: PMC3114568, DOI: 10.1111/j.1440-1819.2010.02164.x.Peer-Reviewed Original ResearchEnlarged right superior temporal gyrus in children and adolescents with autism
Jou RJ, Minshew NJ, Keshavan MS, Vitale MP, Hardan AY. Enlarged right superior temporal gyrus in children and adolescents with autism. Brain Research 2010, 1360: 205-212. PMID: 20833154, PMCID: PMC2990401, DOI: 10.1016/j.brainres.2010.09.005.Peer-Reviewed Original ResearchConceptsRight superior temporal gyrusSuperior temporal gyrusSuperior temporal gyral volumeTemporal gyrusAutism groupLeft superior temporal gyrusSocial perceptual deficitsNeurodevelopmental disordersTotal brain volumeBrain volumePerceptual deficitsSocial perceptionSocial interactionLanguage processingAutismNeuroanatomical basisGroup differencesGyrusGyral volumeAdolescentsDeficitsVolumetric alterationsChildrenHealthy controlsDisordersCortical Gyrification in Autistic and Asperger Disorders: A Preliminary Magnetic Resonance Imaging Study
Jou RJ, Minshew NJ, Keshavan MS, Hardan AY. Cortical Gyrification in Autistic and Asperger Disorders: A Preliminary Magnetic Resonance Imaging Study. Journal Of Child Neurology 2010, 25: 1462-1467. PMID: 20413799, PMCID: PMC3115701, DOI: 10.1177/0883073810368311.Peer-Reviewed Original ResearchConceptsAsperger's disorderGyrification indexPreliminary magnetic resonance imaging studyMagnetic resonance imaging studyResonance imaging studyStructural magnetic resonance imagingAutism groupNeurobiological evidenceOrbitofrontal cortexIntelligence quotientCortical foldingAutismFrontal lobeCortical gyrificationMagnetic resonance imagingPreliminary findingsBrain volumeCorpus callosumDistinct syndromeControl groupDisordersImaging studiesResonance imagingInferior regionsCortical contour
2008
Brainstem volumetric alterations in children with autism
Jou RJ, Minshew NJ, Melhem NM, Keshavan MS, Hardan AY. Brainstem volumetric alterations in children with autism. Psychological Medicine 2008, 39: 1347-1354. PMID: 18812009, PMCID: PMC2888007, DOI: 10.1017/s0033291708004376.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderBrain StemChildChild Development Disorders, PervasiveDominance, CerebralHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNerve Fibers, MyelinatedNerve NetOrgan SizeReference ValuesSoftwareStatistics as TopicSurveys and QuestionnairesWechsler ScalesConceptsTotal brain volumeWhite matter volumeSensory Profile questionnaireGray matter volumeMagnetic resonance imaging (MRI) scansResonance imaging scansAge-matched controlsSignificant differencesGray matter structuresBrainstem abnormalitiesBrainstem circuitrySensory deficitsSensory dysfunctionImaging scansWhite matter structuresVolumetric alterationsBrainstem volumeBrain volumeProfile questionnaireVolumetric measurementsRetarded boySensory sensitivity
2005
Retrospective Study of Quetiapine in Children and Adolescents with Pervasive Developmental Disorders
Hardan A, Jou R, Handen B. Retrospective Study of Quetiapine in Children and Adolescents with Pervasive Developmental Disorders. Journal Of Autism And Developmental Disorders 2005, 35: 387-391. PMID: 16119479, DOI: 10.1007/s10803-005-3306-1.Peer-Reviewed Original ResearchConceptsRetrospective studyPervasive developmental disorderTolerability of quetiapinePlacebo-controlled studyDevelopmental disordersAdverse eventsChart reviewConsecutive outpatientsTreatment terminationQuetiapineHyperactivity subscaleDevelopmental disabilitiesDisordersChildrenAdolescentsParent scaleTolerabilitySedationPatientsOutpatientsClinicRespondersRetrospective Assessment of Atomoxetine in Children and Adolescents with Pervasive Developmental Disorders
Jou R, Handen B, Hardan A. Retrospective Assessment of Atomoxetine in Children and Adolescents with Pervasive Developmental Disorders. Journal Of Child And Adolescent Psychopharmacology 2005, 15: 325-330. PMID: 15910217, DOI: 10.1089/cap.2005.15.325.Peer-Reviewed Original ResearchConceptsConners' Parent Rating ScalePervasive developmental disorderConcomitant medicationsClinical Global Impression ScaleTolerability of atomoxetinePlacebo-controlled studyGlobal Impression ScaleGlobal improvement itemSevere mood swingsDevelopmental disordersCPRS subscaleMost patientsClinic registryRetrospective studyImpression ScaleTreatment responseTreatment doseClinical informationPatientsAtomoxetineSecondary symptomsParent Rating ScaleMood swingsRating ScaleRetrospective assessment
2004
Reduced cortical folding in individuals at high risk for schizophrenia: a pilot study
Jou RJ, Hardan AY, Keshavan MS. Reduced cortical folding in individuals at high risk for schizophrenia: a pilot study. Schizophrenia Research 2004, 75: 309-313. PMID: 15885522, DOI: 10.1016/j.schres.2004.11.008.Peer-Reviewed Original ResearchA Retrospective Assessment of Topiramate in Children and Adolescents with Pervasive Developmental Disorders
Hardan A, Jou R, Handen B. A Retrospective Assessment of Topiramate in Children and Adolescents with Pervasive Developmental Disorders. Journal Of Child And Adolescent Psychopharmacology 2004, 14: 426-432. PMID: 15650499, DOI: 10.1089/cap.2004.14.426.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderOpen-label retrospective studyClinical Global Impression ScalePlacebo-controlled studyRetrospective chart reviewNovel antiepileptic drugGlobal Impression ScaleGlobal improvement itemDevelopmental disordersOpenlabel studyConcomitant medicationsChart reviewSkin rashAdjunctive treatmentSeizure disorderAntiepileptic drugsOutpatient clinicRetrospective studyMean doseImpression ScaleMedical recordsTreatment responsePatientsSide effectsTreatment durationIncreased frontal cortical folding in autism: a preliminary MRI study
Hardan A, Jou R, Keshavan M, Varma R, Minshew N. Increased frontal cortical folding in autism: a preliminary MRI study. Psychiatry Research 2004, 131: 263-268. PMID: 15465295, DOI: 10.1016/j.pscychresns.2004.06.001.Peer-Reviewed Original Research