2024
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Mevenkamp J, Bruls Y, Mancilla R, Grevendonk L, Wildberger J, Brouwers K, Hesselink M, Schrauwen P, Hoeks J, Houtkooper R, Buitinga M, de Graaf R, Lindeboom L, Schrauwen-Hinderling V. Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T. Nature Communications 2024, 15: 9159. PMID: 39443469, PMCID: PMC11499639, DOI: 10.1038/s41467-024-53292-4.Peer-Reviewed Original ResearchConceptsPhysically active older adultsActive older adultsMetabolic healthHuman skeletal musclePhosphorous magnetic resonance spectroscopySedentary individualsOlder adultsStimulate mitochondrial biogenesisHealthSkeletal muscleMitochondrial biogenesisNAD+Physiological decreaseNADH contentNADHQuantify NADHClinical 3Magnetic resonance spectroscopy techniquesMR sequencesAdultsMeasurement reproducibilityA Flow-based Truncated Denoising Diffusion Model for super-resolution Magnetic Resonance Spectroscopic Imaging
Dong S, Cai Z, Hangel G, Bogner W, Widhalm G, Huang Y, Liang Q, You C, Kumaragamage C, Fulbright R, Mahajan A, Karbasi A, Onofrey J, de Graaf R, Duncan J. A Flow-based Truncated Denoising Diffusion Model for super-resolution Magnetic Resonance Spectroscopic Imaging. Medical Image Analysis 2024, 99: 103358. PMID: 39353335, DOI: 10.1016/j.media.2024.103358.Peer-Reviewed Original ResearchDenoising diffusion modelsDeep learning-based super-resolution methodsLearning-based super-resolution methodsMulti-scale super-resolutionGenerative modelSuper-resolution methodsDeep learning modelsHigh-resolution magnetic resonance spectroscopic imagingHigh-quality imagesPost-processing approachSuper-resolutionFlow-based networksLearning modelsLow resolutionTruncation stepLow-resolution dataSharpness adjustmentNetworkSensitivity restrictionsUncertainty estimationDiffusion modelImagesCapabilitySampling processSpectroscopic imagingHigh-quality lipid suppression and B0 shimming for human brain 1H MRSI
Kumaragamage C, McIntyre S, Nixon T, De Feyter H, de Graaf R. High-quality lipid suppression and B0 shimming for human brain 1H MRSI. NeuroImage 2024, 300: 120845. PMID: 39276817, DOI: 10.1016/j.neuroimage.2024.120845.Peer-Reviewed Original ResearchOuter volume suppressionInner volume selectionSlice coverageField shimmingLipid suppressionMRSI acquisitionMagnetic field shimmingMagnetic resonance spectroscopic imagingSpherical harmonic fieldsBrain non-invasivelyAxial coverageMulti-coilRadio frequencyVolume suppressionB0 shimmingBrain coverageGradient coilsHarmonic fieldVolume selectionGradient insertShimming performancePhantom experimentsField variationsSpectroscopic imagingProton magnetic resonance spectroscopic imagingIndirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array
Jacobs S, Prompers J, van der Kemp W, van der Velden T, Gosselink M, Meliadò E, Hoogduin H, Mason G, de Graaf R, Miller C, Bredael G, van der Kolk A, Alborahal C, Klomp D, Wiegers E. Indirect 1H–[13C] MRS of the human brain at 7 T using a 13C‐birdcage coil and eight transmit–receive 1H‐dipole antennas with a 32‐channel 1H‐receive array. NMR In Biomedicine 2024, 37: e5195. PMID: 38845018, DOI: 10.1002/nbm.5195.Peer-Reviewed Original ResearchStimulated echo acquisition modeSignal-to-noise ratioSlice-selective excitationAdiabatic selective refocusingUltra-high fieldIncreased spectral dispersionEcho acquisition modeSpectral dispersionVoxel positionSemi-localPhantomAcquisition modeElectromagnetic simulationsHuman brainSAR limitsExcitationBi-frontalSLASERHealthy volunteersSpectraLipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge
de Graaf R, Liu Y, Corbin Z, De Feyter H. Lipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge. Magnetic Resonance 2024, 5: 21-31. DOI: 10.5194/mr-5-21-2024.Peer-Reviewed Original Research
2023
Imaging metabolism of deuterated glucose in patients with primary brain tumors
Corbin Z, Liu Y, Fulbright R, Thaw-Poon S, Baehring J, Blondin N, Kim P, Omuro A, Chiang V, Moliterno J, Omay S, Piepmeier J, Rothman D, de Graaf R, De Feyter H. Imaging metabolism of deuterated glucose in patients with primary brain tumors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0142.Peer-Reviewed Original ResearchIn vivo demonstration of arbitrary ROI shaping and B0 shimming with MC-ECLIPSE for applications in human brain proton MRSI
Kumaragamage C, McIntyre S, Nixon T, De Feyter H, de Graaf R. In vivo demonstration of arbitrary ROI shaping and B0 shimming with MC-ECLIPSE for applications in human brain proton MRSI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/1238.Peer-Reviewed Original ResearchParallel Proton and Deuterium Metabolic Imaging
Liu Y, Kumaragamage C, Nixon T, McIntyre S, De Feyter H, de Graaf R. Parallel Proton and Deuterium Metabolic Imaging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3870.Peer-Reviewed Original ResearchExpanding interleaved MRI-DMI to 3D SWI (Susceptibility Weighted Imaging) : A truncated acquisition approach
Liu Y, Corbin Z, Fulbright R, Nixon T, McIntyre S, De Feyter H, de Graaf R. Expanding interleaved MRI-DMI to 3D SWI (Susceptibility Weighted Imaging) : A truncated acquisition approach. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0013.Peer-Reviewed Original ResearchRobust and Automated Processing of Deuterium Metabolic Imaging (DMI) using Spatial Prior Knowledge
de Graaf R, Liu Y, Corbin Z, De Feyter H. Robust and Automated Processing of Deuterium Metabolic Imaging (DMI) using Spatial Prior Knowledge. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/4107.Peer-Reviewed Original ResearchReproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion
Ahmadian N, Jacobs S, Gosselink M, van der Kemp W, Hoogduin H, Coppoli A, Mason G, de Graaf R, Norouzizadeh H, Mahon C, van Marle S, van Eijsden P, Cerneus D, Miller C, De Lepeleire I, Basile A, Klomp D, Prompers J, Wiegers E. Reproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/5332.Peer-Reviewed Original ResearchMeasurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1H and 1H–[13C] NMR spectroscopy
Chowdhury G, Behar K, Mason G, Rothman D, de Graaf R. Measurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1H and 1H–[13C] NMR spectroscopy. NMR In Biomedicine 2023, 37: e4957. PMID: 37088548, PMCID: PMC10590826, DOI: 10.1002/nbm.4957.Peer-Reviewed Original ResearchDesign and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner
Theilenberg S, Shang Y, Ghazouani J, Kumaragamage C, Nixon T, McIntyre S, Vaughan J, Parkinson B, Garwood M, de Graaf R, Juchem C. Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner. Magnetic Resonance In Medicine 2023, 90: 1228-1241. PMID: 37145035, PMCID: PMC10330274, DOI: 10.1002/mrm.29692.Peer-Reviewed Original ResearchConceptsMulti-coil arraysMC arraysDuty cycleGeneration capabilityT headNonlinear magnetic fieldHigh duty cycleThermal behaviorBench testingField controlRamp timeResidual imperfectionField generationScanner designMagnetic fieldMC hardwareLinear gradientMRI scannerArrayCapabilityDesignHardwareImage encodingFieldMagnetsMapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)
Ip K, Thomas M, Behar K, de Graaf R, De Feyter H. Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI). Frontiers In Cellular Neuroscience 2023, 17: 1130816. PMID: 37187610, PMCID: PMC10175635, DOI: 10.3389/fncel.2023.1130816.Peer-Reviewed Original ResearchBrain tumorsNormal brainHigh tumorCholine uptakeRG2 cellsCholine infusionMetabolic imagingExogenous cholineMetabolic imaging techniquesDeuterium metabolic imagingIntravenous infusionRG2 tumorsTumor lesionsAnimal modelsCholine metabolismTumorsInfusionRat glioblastomaIntracellular cholineFree cholineHigh uptakeLesionsCholineRatsDeuterated cholineIn vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline values
2022
Flow-Based Visual Quality Enhancer for Super-Resolution Magnetic Resonance Spectroscopic Imaging
Dong S, Hangel G, Chen E, Sun S, Bogner W, Widhalm G, You C, Onofrey J, de Graaf R, Duncan J. Flow-Based Visual Quality Enhancer for Super-Resolution Magnetic Resonance Spectroscopic Imaging. Lecture Notes In Computer Science 2022, 13609: 3-13. DOI: 10.1007/978-3-031-18576-2_1.Peer-Reviewed Original ResearchAdversarial networkVisual qualityDeep learning-based super-resolution methodsLearning-based super-resolution methodsFlow-based modelImage visual qualityGenerative adversarial networkHigh visual qualitySuper-resolution methodSuper-resolved imagesGenerative modelHigh-resolution imagesImage modalitiesFlow-based methodNetworkLow spatial resolutionUncertainty estimationImagesPromising resultsEnhancer networkAnatomical informationHigh fidelityEssential toolDatasetQuality adjustmentMulti-scale Super-Resolution Magnetic Resonance Spectroscopic Imaging with Adjustable Sharpness
Dong S, Hangel G, Bogner W, Widhalm G, Rössler K, Trattnig S, You C, de Graaf R, Onofrey J, Duncan J. Multi-scale Super-Resolution Magnetic Resonance Spectroscopic Imaging with Adjustable Sharpness. Lecture Notes In Computer Science 2022, 13436: 410-420. DOI: 10.1007/978-3-031-16446-0_39.Peer-Reviewed Original ResearchDeuterium metabolic imaging of the human brain in vivo at 7 T
Roig E, De Feyter HM, Nixon TW, Ruhm L, Nikulin AV, Scheffler K, Avdievich NI, Henning A, de Graaf R. Deuterium metabolic imaging of the human brain in vivo at 7 T. Magnetic Resonance In Medicine 2022, 89: 29-39. PMID: 36063499, PMCID: PMC9756916, DOI: 10.1002/mrm.29439.Peer-Reviewed Original ResearchHuman brain POCE MRS at 7T using a 13C birdcage coil and 8 transmit-receive 1H antennas with a 32-channel 1H receive array
Jacobs S, Prompers J, van der Kemp W, van der Velden T, Gosselink M, Meliadò E, Hoogduin H, Mason G, de Graaf R, van der Kolk A, Alborahal C, Klomp D, Wiegers E. Human brain POCE MRS at 7T using a 13C birdcage coil and 8 transmit-receive 1H antennas with a 32-channel 1H receive array. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/1536.Peer-Reviewed Original ResearchInterleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo
Liu Y, De Feyter HM, Fulbright RK, McIntyre S, Nixon TW, de Graaf R. Interleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo. Magnetic Resonance In Medicine 2022, 88: 28-37. PMID: 35225375, PMCID: PMC9924309, DOI: 10.1002/mrm.29196.Peer-Reviewed Original Research