2024
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Mevenkamp J, Bruls Y, Mancilla R, Grevendonk L, Wildberger J, Brouwers K, Hesselink M, Schrauwen P, Hoeks J, Houtkooper R, Buitinga M, de Graaf R, Lindeboom L, Schrauwen-Hinderling V. Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T. Nature Communications 2024, 15: 9159. PMID: 39443469, PMCID: PMC11499639, DOI: 10.1038/s41467-024-53292-4.Peer-Reviewed Original ResearchConceptsPhysically active older adultsActive older adultsMetabolic healthHuman skeletal musclePhosphorous magnetic resonance spectroscopySedentary individualsOlder adultsStimulate mitochondrial biogenesisHealthSkeletal muscleMitochondrial biogenesisNAD+Physiological decreaseNADH contentNADHQuantify NADHClinical 3Magnetic resonance spectroscopy techniquesMR sequencesAdultsMeasurement reproducibility
2023
Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner
Theilenberg S, Shang Y, Ghazouani J, Kumaragamage C, Nixon T, McIntyre S, Vaughan J, Parkinson B, Garwood M, de Graaf R, Juchem C. Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner. Magnetic Resonance In Medicine 2023, 90: 1228-1241. PMID: 37145035, PMCID: PMC10330274, DOI: 10.1002/mrm.29692.Peer-Reviewed Original ResearchConceptsMulti-coil arraysMC arraysDuty cycleGeneration capabilityT headNonlinear magnetic fieldHigh duty cycleThermal behaviorBench testingField controlRamp timeResidual imperfectionField generationScanner designMagnetic fieldMC hardwareLinear gradientMRI scannerArrayCapabilityDesignHardwareImage encodingFieldMagnets
2022
Deuterium metabolic imaging of the human brain in vivo at 7 T
Roig E, De Feyter HM, Nixon TW, Ruhm L, Nikulin AV, Scheffler K, Avdievich NI, Henning A, de Graaf R. Deuterium metabolic imaging of the human brain in vivo at 7 T. Magnetic Resonance In Medicine 2022, 89: 29-39. PMID: 36063499, PMCID: PMC9756916, DOI: 10.1002/mrm.29439.Peer-Reviewed Original ResearchInterleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo
Liu Y, De Feyter HM, Fulbright RK, McIntyre S, Nixon TW, de Graaf R. Interleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo. Magnetic Resonance In Medicine 2022, 88: 28-37. PMID: 35225375, PMCID: PMC9924309, DOI: 10.1002/mrm.29196.Peer-Reviewed Original Research
2021
NMR visibility of deuterium‐labeled liver glycogen in vivo
De Feyter HM, Thomas MA, Behar KL, de Graaf R. NMR visibility of deuterium‐labeled liver glycogen in vivo. Magnetic Resonance In Medicine 2021, 86: 62-68. PMID: 33590529, PMCID: PMC8005460, DOI: 10.1002/mrm.28717.Peer-Reviewed Original ResearchAnimalsDeuteriumGlucoseLiverLiver GlycogenMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMice
2020
Water and lipid suppression techniques for advanced 1H MRS and MRSI of the human brain: Experts' consensus recommendations
Tkáč I, Deelchand D, Dreher W, Hetherington H, Kreis R, Kumaragamage C, Považan M, Spielman DM, Strasser B, de Graaf R. Water and lipid suppression techniques for advanced 1H MRS and MRSI of the human brain: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4459. PMID: 33327042, PMCID: PMC8569948, DOI: 10.1002/nbm.4459.Peer-Reviewed Original ResearchMeSH KeywordsBrainConsensusExpert TestimonyHumansLipidsMagnetic Resonance ImagingMetabolomeProton Magnetic Resonance SpectroscopyRadio WavesSignal Processing, Computer-AssistedWaterContribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations
Cudalbu C, Behar KL, Bhattacharyya PK, Bogner W, Borbath T, de Graaf R, Gruetter R, Henning A, Juchem C, Kreis R, Lee P, Lei H, Marjańska M, Mekle R, Murali‐Manohar S, Považan M, Rackayová V, Simicic D, Slotboom J, Soher BJ, Starčuk Z, Starčuková J, Tkáč I, Williams S, Wilson M, Wright AM, Xin L, Mlynárik V. Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4393. PMID: 33236818, PMCID: PMC10072289, DOI: 10.1002/nbm.4393.Peer-Reviewed Original ResearchECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI
Kumaragamage C, De Feyter HM, Brown P, McIntyre S, Nixon TW, de Graaf R. ECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI. NMR In Biomedicine 2020, 34: e4415. PMID: 33001485, PMCID: PMC9472321, DOI: 10.1002/nbm.4415.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainComputer SimulationFemaleHumansLipidsMagnetic Resonance ImagingMalePhantoms, ImagingProtonsRadio WavesWaterB0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations
Juchem C, Cudalbu C, de Graaf R, Gruetter R, Henning A, Hetherington H, Boer V. B0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4350. PMID: 32596978, DOI: 10.1002/nbm.4350.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalibrationComputer SimulationConsensusExpert TestimonyHumansMagnetic FieldsMagnetic Resonance ImagingSignal Processing, Computer-AssistedDynamic multicoil technique (DYNAMITE) MRI on human brain
Juchem C, Theilenberg S, Kumaragamage C, Mullen M, DelaBarre L, Adriany G, Brown PB, McIntyre S, Nixon TW, Garwood M, de Graaf R. Dynamic multicoil technique (DYNAMITE) MRI on human brain. Magnetic Resonance In Medicine 2020, 84: 2953-2963. PMID: 32544274, PMCID: PMC8168279, DOI: 10.1002/mrm.28323.Peer-Reviewed Original ResearchConceptsGradient coilsConventional gradient coilsField controlMagnetic field gradientImage fidelityShim systemBiot-Savart lawFirst realizationCylindrical surfaceCoil technologyGradient technologyImage distortion correctionGradient fieldGradient errorsField imperfectionsHuman headCoilGeometric deformationMR environmentField gradientLinear xDistortion correctionResolution phantomSpatial encodingNumerical integration
2019
On the magnetic field dependence of deuterium metabolic imaging
de Graaf R, Hendriks AD, Klomp DWJ, Kumaragamage C, Welting D, de Castro C, Brown PB, McIntyre S, Nixon TW, Prompers JJ, De Feyter HM. On the magnetic field dependence of deuterium metabolic imaging. NMR In Biomedicine 2019, 33: e4235. PMID: 31879985, PMCID: PMC7141779, DOI: 10.1002/nbm.4235.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarbon-13 Magnetic Resonance SpectroscopyDeuteriumHumansMagnetic FieldsMagnetic Resonance ImagingPhantoms, ImagingRatsSignal-To-Noise RatioRobust outer volume suppression utilizing elliptical pulsed second order fields (ECLIPSE) for human brain proton MRSI
Kumaragamage C, De Feyter HM, Brown P, McIntyre S, Nixon TW, de Graaf R. Robust outer volume suppression utilizing elliptical pulsed second order fields (ECLIPSE) for human brain proton MRSI. Magnetic Resonance In Medicine 2019, 83: 1539-1552. PMID: 31742799, PMCID: PMC6982600, DOI: 10.1002/mrm.28047.Peer-Reviewed Original Research
2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingCase-Control StudiesDeuteriumGliomaGlucoseHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedRatsRats, Inbred F344ConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approachElliptical localization with pulsed second‐order fields (ECLIPSE) for robust lipid suppression in proton MRSI
de Graaf R, Brown PB, De Feyter HM, McIntyre S, Nixon TW. Elliptical localization with pulsed second‐order fields (ECLIPSE) for robust lipid suppression in proton MRSI. NMR In Biomedicine 2018, 31: e3949. PMID: 29985532, PMCID: PMC6108906, DOI: 10.1002/nbm.3949.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainHumansLipidsMagnetic Resonance ImagingPhantoms, ImagingProton Magnetic Resonance Spectroscopy
2016
The public multi‐coil information (PUMCIN) policy
Juchem C, de Graaf R. The public multi‐coil information (PUMCIN) policy. Magnetic Resonance In Medicine 2016, 78: 2042-2047. PMID: 27905145, PMCID: PMC5453847, DOI: 10.1002/mrm.26558.Peer-Reviewed Original ResearchEquipment DesignHumansInformation DisseminationMagnetic FieldsMagnetic Resonance ImagingRadio WavesSocieties, MedicalDetection of cerebral NAD+ in humans at 7T
de Graaf R, De Feyter H, Brown PB, Nixon TW, Rothman DL, Behar KL. Detection of cerebral NAD+ in humans at 7T. Magnetic Resonance In Medicine 2016, 78: 828-835. PMID: 27670385, PMCID: PMC5366282, DOI: 10.1002/mrm.26465.Peer-Reviewed Original Research
2013
In vivo GABA T2 determination with J‐refocused echo time extension at 7 T
Andreychenko A, Klomp D, de Graaf R, Luijten P, Boer V. In vivo GABA T2 determination with J‐refocused echo time extension at 7 T. NMR In Biomedicine 2013, 26: 1596-1601. PMID: 23893556, DOI: 10.1002/nbm.2997.Peer-Reviewed Original ResearchMeSH KeywordsCreatineGamma-Aminobutyric AcidHumansMagnetic Resonance ImagingPhantoms, ImagingSignal Processing, Computer-AssistedTime FactorsConceptsCoupled spin systemsSpin systemsRelaxation timeEcho timeJ-coupled spinsT. A methodMultiple echo timesEdited signalSpectral editing techniquesShort echo timeT2 decay curvesT2 decayJ-couplingMEGA-sLASERTarget resonancesJ-modulationShape correctionEdited spectraDecay curvesResonanceT2 determinationT2 relaxation timesSpinSignal intensityDecayIn vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Coman D, de Graaf R, Rothman DL, Hyder F. In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR In Biomedicine 2013, 26: 1589-1595. PMID: 23881869, PMCID: PMC3800475, DOI: 10.1002/nbm.2995.Peer-Reviewed Original ResearchConceptsK-spaceNonexchanging protonsThree-dimensional molecular imagingParamagnetic lanthanide ionsRedundant deviationChemical shift imagingField of viewMolecular imaging capabilitiesMolecular imagingRapid data acquisitionProton detectionLanthanide ionsTens of minutesImaging capabilitiesMacrocyclic chelatesSpectroscopic signalsMacrocyclicCSI experimentsRelaxation timeHigh spatiotemporal resolutionParamagnetic agents
2011
Multislice 1H MRSI of the human brain at 7 T using dynamic B0 and B1 shimming
Boer VO, Klomp DW, Juchem C, Luijten PR, de Graaf RA. Multislice 1H MRSI of the human brain at 7 T using dynamic B0 and B1 shimming. Magnetic Resonance In Medicine 2011, 68: 662-670. PMID: 22162089, PMCID: PMC3306521, DOI: 10.1002/mrm.23288.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrain ChemistryHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMolecular ImagingProtonsSensitivity and SpecificityConceptsMagnetic fieldRadio frequency power depositionHigh magnetic fieldsMagnetic field shimmingRadio frequency controlUltra-high fieldMagnetic field inhomogeneityChemical shift resolutionMagnetic field homogeneityField shimmingPower depositionSpectroscopic imaging sequenceField inhomogeneityNew acquisition strategyField homogeneitySpectroscopic imagingShimmingInhomogeneityFieldDynamic B0Nutation angleHigh sensitivityB0ImagingImaging sequenceDynamic multi-coil shimming of the human brain at 7T
Juchem C, Nixon TW, McIntyre S, Boer VO, Rothman DL, de Graaf RA. Dynamic multi-coil shimming of the human brain at 7T. Journal Of Magnetic Resonance 2011, 212: 280-288. PMID: 21824794, PMCID: PMC3183127, DOI: 10.1016/j.jmr.2011.07.005.Peer-Reviewed Original Research