2008
Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats
Yono M, Mane SM, Lin A, Weiss RM, Latifpour J. Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats. Life Sciences 2008, 83: 192-197. PMID: 18619471, DOI: 10.1016/j.lfs.2008.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Gene Expression ProfilingInsulinMaleProstateRatsRats, Inbred BBReverse Transcriptase Polymerase Chain ReactionStreptozocinConceptsProstate growthMRNA expression levelsBio-BreedingDiabetic groupExpression levelsVentral prostateSTZ-diabetic ratsReal-time reverse transcription-polymerase chain reactionSTZ-induced diabeticReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMicroarray analysisHyperglycemic diabetes
2005
Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes
Yono M, Pouresmail M, Takahashi W, Flanagan JF, Weiss RM, Latifpour J. Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes. Naunyn-Schmiedeberg's Archives Of Pharmacology 2005, 372: 251-255. PMID: 16235050, DOI: 10.1007/s00210-005-0010-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDisease Models, AnimalHyperglycemiaHypoglycemic AgentsInsulinMaleOrgan SizeRatsRats, Inbred BBStreptozocinUrogenital SystemConceptsSTZ-induced diabetesBB ratsSpontaneous diabetesGenitourinary tractInsulin treatmentDiabetes-resistant BB ratsDiabetes-prone BB ratsHyperglycemic diabetic ratsStreptozotocin-induced diabetesSerum testosterone levelsSignificant decreaseGroups of ratsEuglycemic diabeticsEuglycemic groupTissue weight changesBladder weightDiabetic ratsSuboptimal doseAdrenal glandHyperglycemic groupDiabetic studyTestosterone levelsDiabetesControl groupVentral prostate
2002
The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate
Takahashi W, Afiatpour P, Foster H, Ikeda K, Wada Y, Weiss RM, Latifpour J. The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate. Naunyn-Schmiedeberg's Archives Of Pharmacology 2002, 366: 166-176. PMID: 12122504, DOI: 10.1007/s00210-002-0575-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesAutoradiographyDiabetes Mellitus, ExperimentalDNA PrimersEndothelin-1Endothelin-3Endothelin-Converting EnzymesGene ExpressionMaleMetalloendopeptidasesMicroscopyOrchiectomyOrgan SizeProstateProtein BindingRadioligand AssayRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsReceptor subtype mRNAsET receptor subtypesSerum testosterone levelsET receptorsRat prostateEffects of castrationReceptor subtypesSubtype mRNAsDorsolateral regionTestosterone levelsET-1Three-month-old SpraguePharmacological propertiesDiabetes-induced reductionET receptor systemET-3 mRNAETB receptor subtypesPost-operative dayReverse transcription-polymerase chain reactionVentral regionECE-1 mRNATranscription-polymerase chain reactionLight microscopy autoradiographyEnzyme-1 mRNAMultiplex reverse transcription-polymerase chain reaction
2001
Regulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland
Ikeda K, Wada Y, Sanematsu H, Foster HE, Shin D, Weiss RM, Latifpour J. Regulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland. Journal Of Endocrinology 2001, 168: 163-175. PMID: 11139780, DOI: 10.1677/joe.0.1680163.Peer-Reviewed Original ResearchConceptsEndothelin-converting enzyme-1Rat adrenal glandET receptor subtypesInduction of diabetesAdrenal glandReceptor subtypesETB receptorsExperimental diabetesAge-matched control ratsECE-1 mRNA levelsET-3 mRNAPredominant receptor subtypeDiabetes-induced changesEndothelin receptor subtypesInsulin-treated diabeticsSecretion of steroidsReceptor subtypes ETARadioligand receptor bindingAdrenal gland sizeET-1 mRNAExpression levelsRegulatory effectsVascular toneET receptorsEndothelin action
2000
EXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-β
IKEDA K, WADA Y, FOSTER H, WANG Z, WEISS R, LATIFPOUR J. EXPERIMENTAL DIABETES-INDUCED REGRESSION OF THE RAT PROSTATE IS ASSOCIATED WITH AN INCREASED EXPRESSION OF TRANSFORMING GROWTH FACTOR-β. Journal Of Urology 2000, 164: 180-185. PMID: 10840456, DOI: 10.1016/s0022-5347(05)67491-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalMaleProstateRatsRats, Sprague-DawleyRNA, MessengerTransforming Growth Factor betaConceptsSerum testosterone levelsDiabetic rat prostateTestosterone levelsRat prostateProstatic weightProtein levelsStromal cellsAge-matched control ratsGrowth factorInsulin-treated diabeticsInduction of diabetesProstatic stromal cellsSemi-quantitative Western blottingTGF-beta expressionTGF-beta2 expressionTransforming Growth FactorAndrogen-dependent processesExperimental diabetesMultiplex RT-PCRControl ratsImmunohistochemical studyTGF-beta2TGF-beta1Prostate glandProstateExpression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment
Saito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalEndothelin Receptor AntagonistsEndothelin-1InsulinIodine RadioisotopesMaleOrgan SizeProstateProtein IsoformsRadioligand AssayRandom AllocationRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneUp-RegulationConceptsInduction of diabetesET receptorsReverse transcription-polymerase chain reactionRat prostateInsulin treatmentDiabetic animalsReceptor subtypesDiabetes-induced upregulationET receptor densityEndothelin receptor subtypesET receptor subtypesSTZ-injected ratsSerum testosterone levelsRadioligand receptor bindingDiabetic rat prostateTranscription-polymerase chain reactionDiabetic ratsETB receptorsSmaller prostatesEndothelin receptorsProstatic stromaTestosterone levelsReceptor densityPharmacological profileAutoradiographic studyExpression and localization of basic fibroblast growth factor in diabetic rat prostate
Wang Z, Ikeda K, Wada Y, Foster H, Weiss R, Latifpour J. Expression and localization of basic fibroblast growth factor in diabetic rat prostate. BJU International 2000, 85: 945-952. PMID: 10792180, DOI: 10.1046/j.1464-410x.2000.00597.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternDiabetes Mellitus, ExperimentalFibroblast Growth Factor 2ImmunohistochemistryMaleProstateRatsRats, Sprague-DawleyConceptsBenign prostatic hyperplasiaDiabetic ratsExpression of FGF2Testosterone levelsRat prostateLow serum testosterone levelsHuman benign prostatic hyperplasiaAge-matched control ratsWestern blottingSerum testosterone levelsPolymerase chain reaction studiesDiabetic rat prostateReverse transcriptase-polymerase chain reaction studiesGroups of ratsBasic fibroblast growth factorImmuno-histochemical studyFibroblast growth factor-2Fibroblast growth factorProstatic sectionsFGF-2 mRNAGrowth factor 2Smaller prostatesProstatic hyperplasiaProstatic sizeProstatic growthGene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
Saito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyDiabetes Mellitus, ExperimentalEndothelin-1MaleOligopeptidesPeptides, CyclicRatsRats, Sprague-DawleyReceptors, EndothelinRNA, MessengerStreptozocinUrinary BladderConceptsRat bladder domeEndothelin receptorsBladder domeInsulin treatmentReceptor subtypesFunctional endothelin receptorsMammalian urinary tractEndothelin receptor subtypesInduction of diabetesAge-matched controlsReceptor alterationsExperimental diabetesUrinary tractPharmacological characterizationPharmacological profileMuscular layerMRNA upregulationAutoradiographic studyTranscription-polymerase chain reaction dataReceptorsExpression levelsDiabetesTissue componentsSubtypesTreatment
1999
Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter
Saito M, Weiss R, Latifpour J. Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter. International Journal Of Urology 1999, 6: 361-368. PMID: 10445306, DOI: 10.1046/j.1442-2042.1999.00074.x.Peer-Reviewed Original Research
1998
Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes
Nishi K, Wada Y, Saito M, Foster H, Weiss R, Latifpour J. Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes. Urologia Internationalis 1998, 61: 147-153. PMID: 9933834, DOI: 10.1159/000030311.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AntagonistsAnalysis of VarianceAnimalsBinding SitesCulture TechniquesDiabetes Mellitus, ExperimentalDisease Models, AnimalDown-RegulationLinear ModelsMaleProstateRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReference ValuesSpleenStreptozocinSubmandibular GlandVas DeferensConceptsRat prostateAlpha-1 adrenergic receptorsInduction of diabetesSTZ-induced diabetesWeeks of streptozotocinDiabetic rat prostateSimilar pharmacological profileReceptor subtype specificityExperimental diabetesAlpha1A-subtypeRat submaxillary glandReceptor-binding experimentsRat vasPharmacological profileDiabetesProstateSubtype specificityPharmacological propertiesKi valuesSubmaxillary glandRat spleenPrazosinWB4101BMY7378Spiperone
1997
Experimental Diabetes Upregulates the Expression of Uretereral Endothelin Receptors
Nakamura I, Saito M, Fukumoto Y, Yoshida M, Nishi K, Weiss R, Latifpour J. Experimental Diabetes Upregulates the Expression of Uretereral Endothelin Receptors. Peptides 1997, 18: 1091-1093. PMID: 9357071, DOI: 10.1016/s0196-9781(97)00026-0.Peer-Reviewed Original Research
1996
Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens
Saito M, Nishi K, Fukumoto Y, Weiss R, Latifpour J. Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens. Biochemical Pharmacology 1996, 52: 1593-1598. PMID: 8937475, DOI: 10.1016/s0006-2952(96)00565-5.Peer-Reviewed Original ResearchConceptsET receptorsAge-matched controlsRat vasa deferentiaIRL 1620BQ-610Vasa deferentiaET-1ET-3ETA receptor subtypeGroups of ratsDiabetic ratsExperimental diabetesEndothelin receptorsPlasma levelsReceptor subtypesInsulin treatmentPeripheral tissuesRat vasPharmacological profileReceptor characteristicsFmol/StreptozotocinReceptorsWeeksEndothelinEffect of experimental diabetes on rat prostate endothelin receptors
Saito M, Nishi K, Foster H, Weiss R, Latifpour J. Effect of experimental diabetes on rat prostate endothelin receptors. European Journal Of Pharmacology 1996, 310: 197-200. PMID: 8884217, DOI: 10.1016/0014-2999(96)00422-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightDiabetes Mellitus, ExperimentalMaleOrgan SizeProstateRatsRats, Sprague-DawleyReceptors, Endothelin
1995
Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder
Mimata H, Wheeler M, Fukumoto Y, Takigawa H, Nishimoto T, Weiss R, Latifpour J. Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder. Molecular And Cellular Biochemistry 1995, 152: 71-76. PMID: 8609914, DOI: 10.1007/bf01076465.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalHydrolysisMalePhosphatidylinositolsRatsRats, Sprague-DawleyReceptors, MuscarinicSignal TransductionUrinary BladderConceptsDiabetic bladderRat bladderAltered functional responseControl rat bladdersCarbachol-induced increaseMuscarinic receptor densityPhosphatidyl inositol hydrolysisMuscarinic agonist stimulationSucrose-fed animalsRat detrusorContractile responseInositol phosphate productionMuscarinic receptorsMuscarinic agonistsReceptor densityBladderAgonist stimulationPhosphatidylinositol metabolismInositol uptakeEC50 valuesSignal transduction pathwaysPhosphate productionTransduction pathwaysDetrusorStreptozotocin
1994
Diabetes-Induced Alterations in the Properties of Muscarinic Cholinergic Receptors in Rat Vas Deferens
Kamai T, Fukumoto Y, Gousse A, Yoshida M, Davenport T, Weiss R, Latifpour J. Diabetes-Induced Alterations in the Properties of Muscarinic Cholinergic Receptors in Rat Vas Deferens. Journal Of Urology 1994, 152: 1017-1021. PMID: 8051725, DOI: 10.1016/s0022-5347(17)32646-0.Peer-Reviewed Original ResearchConceptsMuscarinic cholinergic receptorsRat vasVas deferensCholinergic receptorsMuscarinic receptorsDiabetic insulin-treated ratsMuscarinic cholinergic receptor subtypesMuscarinic cholinergic receptor densityMembrane particulatesCholinergic receptor densityDiabetes-Induced AlterationsAF-DX 116Cholinergic receptor subtypesMuscarinic cholinergic antagonistAdministration of insulinInsulin-treated ratsAge-matched controlsRat vas deferensRank orderAdditional pharmacological studiesDiabetic ratsBladder domeCerebral cortexCholinergic antagonistsReceptor subtypesReversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors
Fukomoto Y, Yoshida M, Weiss R, Latifpour J. Reversibility of Diabetes- and Diuresis-Induced Alterations in Rat Bladder Dome Muscarinic Receptors. Diabetes 1994, 43: 819-826. PMID: 8194669, DOI: 10.2337/diab.43.6.819.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBody WeightCell MembraneDiabetes Mellitus, ExperimentalDiaminesDiuresisDrinking BehaviorInsulinKineticsMaleMyocardiumOrgan SizeParasympatholyticsPiperidinesPirenzepineProstateQuinuclidinyl BenzilateRatsRats, Sprague-DawleyReceptors, MuscarinicSucroseTestosteroneUp-RegulationUrinary BladderConceptsAge-matched control ratsMuscarinic receptorsRat bladder domeBladder domeDiuretic ratsDiabetic ratsControl ratsSTZ-induced diabetic ratsInsulin-treated diabetic ratsDiabetes-induced upregulationEarly insulin treatmentSucrose-fed ratsGroups of ratsIncreased water intakeBladder hypertrophyUrine outputInsulin treatmentRadioligand receptorRatsDiabetesDiuretic stateReceptorsWater intakeWeeksUpregulation
1993
The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate
Fukumoto Y, Yoshida M, Dokita S, Kamai T, Weiss R, Latifpour J. The Reversal Effect of Insulin on Diabetes-Induced Alterations In Beta Adrenergic and Muscarinic Receptors in Rat Prostate. Journal Of Urology 1993, 149: 1602-1606. PMID: 8388963, DOI: 10.1016/s0022-5347(17)36459-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesDiabetes Mellitus, ExperimentalDown-RegulationInsulinMaleProstateRadioligand AssayRatsRats, Sprague-DawleyReceptors, Adrenergic, betaReceptors, MuscarinicTime FactorsConceptsMuscarinic cholinergic receptorsBeta adrenergicRat prostateCholinergic receptorsInsulin treatmentMuscarinic receptorsInsulin-treated diabetic animalsEarly insulin treatmentDiabetes-induced alterationsInduction of diabetesInsulin-treated diabeticsOnset of diabetesAdministration of streptozotocinDiabetes-induced downregulationDiabetic rat prostateGroups of ratsBeta-adrenergic agonistsHigh-affinity agonistDiabetic animalsMuscarinic agonistsAdrenergic agonistsAdrenergicProstateDiabetesAgonists
1992
Effect of Insulin and Dietary Myoinositol on Muscarinic Receptor Alterations in Diabetic Rat Bladder
Latifpour J, Gousse A, Yoshida M, Weiss R. Effect of Insulin and Dietary Myoinositol on Muscarinic Receptor Alterations in Diabetic Rat Bladder. Journal Of Urology 1992, 147: 760-763. PMID: 1538479, DOI: 10.1016/s0022-5347(17)37374-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalInositolInsulinReceptors, MuscarinicUp-RegulationUrinary BladderConceptsDietary myoinositolBladder domeMuscarinic receptorsReceptor densityLower serum insulin levelsDiabetic rat bladderMuscarinic receptor alterationsStreptozotocin-injected ratsMuscarinic receptor densitySerum insulin levelsHigher serum glucoseGroups of ratsRadioligand receptor binding assaysEffect of insulinReceptor binding assaysHigh water intakeUrine outputDiabetic ratsReceptor alterationsInsulin levelsSerum glucoseRat bladderRatsInsulinInduced abnormalities
1991
Muscarinic receptors in diabetic rat prostate
Latifpour J, Gousse A, Yoshida M, Weiss R. Muscarinic receptors in diabetic rat prostate. Biochemical Pharmacology 1991, 42: s113-s119. PMID: 1768268, DOI: 10.1016/0006-2952(91)90400-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtropineBlood GlucoseDiabetes Mellitus, ExperimentalDown-RegulationInositolInsulinMalePirenzepineProstateQuinuclidinyl BenzilateRatsRats, Inbred StrainsReceptors, MuscarinicConceptsMuscarinic receptorsRat prostateM3 muscarinic receptor subtypesMembrane particulatesAF-DX 116Injection of streptozotocinMuscarinic cholinergic receptorsMuscarinic receptor subtypesSTZ-induced diabetesM3 muscarinic receptorsDiabetic rat prostateLower body weightGroups of ratsInsulin-treated animalsVariety of abnormalitiesDiabetic insulinMuscarinic antagonistSmaller prostatesCholinergic receptorsReceptor subtypesPharmacological profileBody weightFmol/Myo-inositolDiabetesDifferential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes. Diabetes 1991, 40: 1150-1156. PMID: 1657672, DOI: 10.2337/diab.40.9.1150.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsSucrose-fed ratsBladder domeDetrusor stripsDiabetic ratsHigher serum glucose levelsLower serum insulin levelsLarger contractile responsesMuscarinic receptor upregulationHigher urine outputCarbachol-induced contractionDiabetes-induced alterationsMuscarinic cholinergic receptorsSerum insulin levelsSTZ-induced diabetesSerum glucose levelsIsoproterenol-induced relaxationAge-matched controlsLower body weightSucrose-fed animalsBladder hypertrophyContractile responseDiabetic bladderUrine outputRelaxed KCl