2009
Skin immune surveillance by T cells—A new order?
Strid J, Tigelaar RE, Hayday AC. Skin immune surveillance by T cells—A new order? Seminars In Immunology 2009, 21: 110-120. PMID: 19369094, DOI: 10.1016/j.smim.2009.03.002.Peer-Reviewed Original ResearchConceptsImmune surveillanceAdaptive immune surveillanceStress-induced antigensSystemic immune cellsSkin immune surveillanceLocal lymphocytesOrgan dysfunctionDendritic cellsImmune cellsT cellsEpithelial cellsTissue integrityCellsSurveillanceBody surfaceImmunopathologyImmunoregulationDysfunctionLymphocytesInfectionAntigenImmunoprotectionStress response
2008
Development of Immunogenic Tumor-Loaded Dendritic Cells Through Physical Perturbation and Apoptotic Cell Loading
Shen X, Berger CL, Tigelaar R, Edelson RL. Development of Immunogenic Tumor-Loaded Dendritic Cells Through Physical Perturbation and Apoptotic Cell Loading. Immunological Investigations 2008, 37: 798-821. PMID: 18991097, DOI: 10.1080/08820130802403358.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationAntigens, CDAntigens, NeoplasmApoptosisB7-1 AntigenCancer VaccinesCD8-Positive T-LymphocytesCell DifferentiationCell Line, TumorCytotoxicity, ImmunologicDendritic CellsHumansImmunoglobulinsLymphocyte ActivationLymphoma, T-CellMechanotransduction, CellularMembrane GlycoproteinsMonocytesPerforinReceptors, CCR7Silicon DioxideConceptsT cellsDendritic cellsAllogeneic T cell proliferationCD8 T cellsLevels of perforinChemokine receptor CCR7T cell proliferationApoptotic tumor cellsUniverse of antigensDC vaccinesImmunogenic tumorsImmature DCsReceptor CCR7TNF-alphaPassage of leukocytesIFN-gammaHuman monocytesMonocytesTumor cellsPotent inductionCell apoptosisPhenotypic conversionCell proliferationApoptotic cellsCells induces
2000
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
Herrick C, MacLeod H, Glusac E, Tigelaar R, Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. Journal Of Clinical Investigation 2000, 105: 765-775. PMID: 10727445, PMCID: PMC377464, DOI: 10.1172/jci8624.Peer-Reviewed Original ResearchConceptsTh2 responsesIL-13IL-4Th2-type immune responseIL-4-deficient miceTh2-promoting cytokinesOVA-specific IgG1Bronchoalveolar lavage fluidWild-type miceAllergen encounterTh2 sensitizationAirway challengeTh2 activationAllergen exposureAtopic individualsBAL fluidEnvironmental allergensWT miceLavage fluidPrimary exposureVivo depletionAnatomic sitesImmune responseAnimal modelsMice
1998
Intracutaneous vaccination of rabbits with the E6 gene of cottontail rabbit papillomavirus provides partial protection against virus challenge
Sundaram P, Tigelaar R, Xiao W, Brandsma J. Intracutaneous vaccination of rabbits with the E6 gene of cottontail rabbit papillomavirus provides partial protection against virus challenge. Vaccine 1998, 16: 613-623. PMID: 9569473, DOI: 10.1016/s0264-410x(97)84510-0.Peer-Reviewed Original ResearchConceptsCottontail rabbit papillomavirusHumoral immunityControl rabbitsIntracutaneous vaccinationChallenge sitePeripheral blood mononuclear cellsE6 genePartial protectionCRPV E6 proteinsRabbit papillomavirusBlood mononuclear cellsEffect of vaccinationPapillomavirus-induced diseaseE6 proteinMicrograms DNAPartial prophylaxisBooster vaccinationControl vaccineInitial vaccinationProphylactic immunityCellular immunityMononuclear cellsVirus challengeDNA vaccinationPapilloma burden
1994
Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines
Tokura Y, Yagi J, O'Malley J, Lewis J, Takigawa M, Edelson R, Tigelaar R. Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines. Journal Of Investigative Dermatology 1994, 102: 31-38. PMID: 8288908, DOI: 10.1111/1523-1747.ep12371727.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialCell DivisionCells, CulturedCytokinesEnterotoxinsEnzyme-Linked Immunosorbent AssayEpidermal CellsEpidermisExfoliatinsFemaleHistocompatibility Antigens Class IIHumansInterferon-gammaInterleukin-1KeratinocytesLangerhans CellsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred CBASpleenStaphylococcus aureusSuperantigensThymus GlandT-LymphocytesTumor Necrosis Factor-alphaConceptsStaphylococcal enterotoxin BT cell responsesLangerhans cellsT cellsExfoliative toxinAccessory cellsEnterotoxin BTumor necrosisT-cell receptor V beta gene segmentsT cell-activating cytokinesMajor histocompatibility complex (MHC) class II moleculesSuperantigen staphylococcal enterotoxin BMajor histocompatibility complex classMurine epidermal Langerhans cellsT-cell proliferative activityEpidermal Langerhans cellsSplenic T cellsT cell proliferationMurine splenic T cellsHistocompatibility complex classClass II moleculesEnzyme-linked immunosorbentBeta gene segmentsImmunostimulatory moleculesImmunomodulatory cytokines
1991
Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells
Simon J, Cruz P, Tigelaar R, Sontheimer R, Bergstresser P. Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells. Journal Of Investigative Dermatology 1991, 96: 148-151. PMID: 1670950, DOI: 10.1111/1523-1747.ep12515946.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear leukocytesAdhesion molecules CD11aAlloreactive T cellsAntigen-presenting cellsLangerhans cellsT cellsICAM-1T cell activationAdhesion moleculesAccessory signalsAllogeneic peripheral blood mononuclear leukocytesHuman epidermal Langerhans cellsBlood mononuclear leukocytesEpidermal Langerhans cellsEpidermal cellsAdhesion molecule expressionTwo-color immunofluorescenceDependent T-cell activationRelevant adhesion moleculesEfficient T cell activationAllostimulatory capacityHuman epidermal cellsLC stimulationMolecule expressionMononuclear leukocytes
1987
Lack of dendritic Thy-1+ epidermal cells in mice with severe combined immunodeficiency disease.
Nixon-Fulton J, Witte P, Tigelaar R, Bergstresser P, Kumar V. Lack of dendritic Thy-1+ epidermal cells in mice with severe combined immunodeficiency disease. The Journal Of Immunology 1987, 138: 2902-5. PMID: 2883236, DOI: 10.4049/jimmunol.138.9.2902.Peer-Reviewed Original ResearchConceptsDendritic Thy-1SCID miceEpidermal cell suspensionsThy-1NK cellsT lymphocytesEpidermal whole mountsSevere combined immunodeficiency diseaseCombined immunodeficiency diseaseNormal bone marrowControl miceImmunodeficiency diseaseBone marrowWhole mountsMiceImmunofluorescent stainingCon ACell suspensionsEC suspensionsEpidermal cellsLymphocytesPrecursor levelsCellsTransplantationMarrow
1985
Lymphocyte Traffic and the Skin
Tigelaar R. Lymphocyte Traffic and the Skin. Dermatologic Clinics 1985, 3: 569-585. PMID: 3916171, DOI: 10.1016/s0733-8635(18)30857-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapillary PermeabilityCell DivisionCell MovementEndotheliumHumansLymph NodesLymphocyte ActivationLymphocytesLymphomaSkinConceptsPeripheral lymph nodesLymph nodesLymphocyte migrationEndothelial cellsLymphoid organsImmunologic influenceMesenteric lymph nodesMovement of lymphocytesLymphocyte membrane receptorsDifferent organ sitesSpecialized endothelial cellsNonlymphoid organsLymphocyte trafficImmunologic defenseT cellsGastrointestinal tractOrgan sitesBlast transformationMajor subsetSkinLymphocytesCommon determinantsOrgansMembrane receptorsCells
1983
Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.
Elmets C, Bergstresser P, Tigelaar R, Wood P, Streilein J. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. Journal Of Experimental Medicine 1983, 158: 781-794. PMID: 6193234, PMCID: PMC2187099, DOI: 10.1084/jem.158.3.781.Peer-Reviewed Original ResearchConceptsTolerogenic signalsLow-dose ultraviolet B (UVB) radiationLow-dose ultraviolet radiationAntigen-presenting potentialAntigen-specific unresponsivenessResident Langerhans cellsMechanism of unresponsivenessSuppressor cellsContact hypersensitivityLyt-1Effector stageLangerhans cellsSystemic administrationT cellsLocal applicationUltraviolet B radiationInduction phaseB radiationUnresponsivenessSkinUltraviolet radiationCellsTolerogenDNFBHypersensitivity
1976
Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells
Janeway C, Mosier D, Tigelaar R. Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells. European Journal Of Immunology 1976, 6: 747-750. PMID: 138373, DOI: 10.1002/eji.1830061017.Peer-Reviewed Original ResearchConceptsMixed lymphocyte reactionFresh spleen cellsSpleen cellsLymphocyte reactionOne-way mixed-lymphocyte reactionPrimary mixed lymphocyte reactionMouse strainsStimulator activityCytotoxic T cellsStrong mixed lymphocyte reactionsUnrelated mouse strainsCongenic mouse strainsCytotoxic cellsStimulator cellsT cellsRelease assaysSpecific lossCell activityResidual cellsB subregionRestricted expressionLymphocytesSuch cellsAntigenCells