1999
Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects
Bremner J, Horti A, Staib L, Zea‐Ponce Y, Soufer R, Charney D, Baldwin R. Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects. Synapse 1999, 35: 68-77. PMID: 10579810, DOI: 10.1002/(sici)1098-2396(200001)35:1<68::aid-syn9>3.0.co;2-h.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainCarbon RadioisotopesFlumazenilHumansKineticsMaleRadioligand AssayReceptors, GABA-ATomography, Emission-ComputedConceptsBenzodiazepine receptor bindingHealthy human subjectsReceptor bindingBenzodiazepine receptorsHuman subjectsBenzodiazepine receptor antagonistCompartment modelReceptor antagonistMultiple time pointsBolus injectionArterial samplesTime-activity curvesSPECT radioligandBrain tissueBrain tissue compartmentsPET imagingTime pointsPrior reportsRadioligandParent compoundTissue compartmentsRadioligand concentrationHigh specific activityWiley-LissReceptorsQuantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects
Bremner J, Baldwin R, Horti A, Staib L, Ng C, Tan P, Zea-Ponce Y, Zoghbi S, Seibyl J, Soufer R, Charney D, Innis R. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Research 1999, 91: 79-91. PMID: 10515463, DOI: 10.1016/s0925-4927(99)00015-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBenzodiazepine receptorsArterial blood samplesBenzodiazepine receptor bindingHealthy human subjectsHuman subjectsNeuroreceptor bindingSingle photon emissionSingle bolusOccipital cortexBlood samplesTemporal cortexEmission tomographyBrain compartmentsDynamic positron emission tomographyReceptor bindingSPECTSame human subjectsPhoton emissionCortexHuman brainRadioligandPreliminary findingsBrainReceptors
1995
Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil
Baldwin R, Horti A, Bremner J, Stratton M, Dannals R, Ravert H, Zea-Ponce Y, Ng C, Dey H, Soufer R, Charney D, Mazza S, Sparks R, Stubbs J, Innis R. Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil. Nuclear Medicine And Biology 1995, 22: 659-665. PMID: 7581177, DOI: 10.1016/0969-8051(94)00139-b.Peer-Reviewed Original ResearchConceptsHuman biodistribution dataUrinary bladder wallReceptor tracerHealthy human volunteersPositron emission tomographyBladder wallHigh doseBenzodiazepine receptorsTime-activity curvesUseful agentSPECT studiesEmission tomographyHuman volunteersBiodistribution dataAdult baboonsMCi/mumolPET imagingRadiation dosesN-methylEffective dose equivalentInjectionPurity 99MinCortexDose