2016
SH2 Domain–Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis
Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. SH2 Domain–Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 500-514. PMID: 27736153, PMCID: PMC5378419, DOI: 10.1164/rccm.201602-0329oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisProfibrotic stimuliLung fibroblastsChronic fatal lung diseaseMyofibroblast differentiationPrimary human lung fibroblastsFatal lung diseaseNovel therapeutic strategiesVivo therapeutic effectPotential therapeutic usefulnessHuman lung fibroblastsMouse lung fibroblastsDismal prognosisFibroblastic fociLung fibrosisLung diseaseBleomycin modelTherapeutic effectTherapeutic usefulnessTherapeutic strategiesTherapeutic targetTransgenic miceFibrosisSHP2 overexpression
2004
Regulation of pulmonary fibrosis by chemokine receptor CXCR3
Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. Journal Of Clinical Investigation 2004, 114: 291-299. PMID: 15254596, PMCID: PMC449741, DOI: 10.1172/jci16861.Peer-Reviewed Original ResearchConceptsCXC chemokine receptor 3Lung NK cellsCXCR3-deficient miceIFN-gamma productionLung injuryIFN-gammaEnhanced fibrosisNK cellsWT miceChemokine receptors CXC chemokine receptor 3Chemokine MIG/CXCL9Endogenous IFN-gamma productionI-TAC/CXCL11IP-10/CXCL10Inflammatory cell recruitmentProgressive interstitial fibrosisChemokine receptor 3Exogenous IFN-gammaExpression of CXCL10MIG/CXCL9CXCR3 deficiencyAdoptive transferPulmonary injuryLymph nodesPulmonary fibrosis