2016
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells
Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells. Cell Reports 2016, 16: 457-471. PMID: 27346347, PMCID: PMC4945411, DOI: 10.1016/j.celrep.2016.05.087.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAntineoplastic AgentsBrain NeoplasmsCCAAT-Enhancer-Binding ProteinsCell Line, TumorCpG IslandsDNA MethylationDrug Screening Assays, AntitumorErbB ReceptorsGene Expression Regulation, NeoplasticGene SilencingGlioblastomaHumansLung NeoplasmsMAP Kinase Signaling SystemMixed Function OxygenasesMutationOncogenesProtein Kinase InhibitorsProto-Oncogene ProteinsTranscription, GeneticTumor Suppressor ProteinsUp-RegulationConceptsOncogenic epidermal growth factor receptorMethylation-mediated transcriptional silencingEpidermal growth factor receptorTumor suppressorTranscriptional silencingActive DNA demethylationCancer cellsFamily member 1TET1 knockdownDNA demethylaseDNA demethylationTranscription factorsGrowth factor receptorEctopic expressionCytoplasmic localizationGlioblastoma tumor growthLung cancer cellsTET1 expressionFunctional roleSuppressorFactor receptorMember 1TET1SilencingLung cancer samples
2002
Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling
Zhu Z, Zheng T, Lee CG, Homer RJ, Elias JA. Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Seminars In Cell And Developmental Biology 2002, 13: 121-128. PMID: 12127145, DOI: 10.1016/s1084-9521(02)00018-6.Peer-Reviewed Original ResearchConceptsTetracycline-controlled transcriptional silencerTranscriptional activatorTetracycline-controlled transcriptional activatorTetracycline-controlled transcriptional activation systemCultured cellsTranscriptional activation systemTarget gene expressionVariety of genesReverse tetracycline-controlled transcriptional activatorTranscriptional silencerMammalian systemsPresence of doxycyclineTarget genesNumerous transgenesGene expressionWhole organismTarget transgeneResponsive elementBackground expressionTemporal controlRegulatable systemGenesTransgene expressionRegulatorTransgene
2001
Airway Inflammation and Remodeling in Asthma
ZHU Z, LEE C, ZHENG T, CHUPP G, WANG J, HOMER R, NOBLE P, HAMID Q, ELIAS J. Airway Inflammation and Remodeling in Asthma. American Journal Of Respiratory And Critical Care Medicine 2001, 164: s67-s70. PMID: 11734470, DOI: 10.1164/ajrccm.164.supplement_2.2106070.Peer-Reviewed Original ResearchConceptsAirway fibrosisAsthmatic airwaysIL-11IL-13Asthma-like inflammationExaggerated cytokine productionImportance of airwayMucin gene expressionHyaluronic acid accumulationAirway healingAsthmatic tissuesSevere airwayAirway inflammationAirway remodelingAsthmatic subjectsSubepithelial fibrosisAsthma phenotypesCytokine productionMurine airwaysMucous metaplasiaAirwayTransgenic miceNatural historyInterleukin-11Fibrosis
1997
Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.
Ray P, Tang W, Wang P, Homer R, Kuhn C, Flavell RA, Elias JA. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. Journal Of Clinical Investigation 1997, 100: 2501-2511. PMID: 9366564, PMCID: PMC508450, DOI: 10.1172/jci119792.Peer-Reviewed Original Research