2014
Introductory Anatomy, Histology, and Cell Biology of the Lung
Homer R, Britto C. Introductory Anatomy, Histology, and Cell Biology of the Lung. 2014, 2538-2557. DOI: 10.1016/b978-0-12-386456-7.05301-6.Peer-Reviewed Original ResearchMajor anatomical componentsGas exchange regionSmooth muscleSystemic circulationBlood flowConducting airwaysGas exchange unitsHematopoietic elementsHost defenseAirwayProtective mechanismLungParallel conduction pathwaysEnvironmental exposuresHarmful agentsBloodExchange regionAnatomical componentsTissueNerveHistologyReflexInterstitiumAlveoliVasculature
2005
Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms
Homer RJ, Elias JA. Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms. Physiology 2005, 20: 28-35. PMID: 15653837, DOI: 10.1152/physiol.00035.2004.Peer-Reviewed Original Research
2003
Transgenic Modeling of Interleukin-13 in the Lung
Elias JA, Zheng T, Lee CG, Homer RJ, Chen Q, Ma B, Blackburn M, Zhu Z. Transgenic Modeling of Interleukin-13 in the Lung. CHEST Journal 2003, 123: 339s-345s. PMID: 12628968, DOI: 10.1378/chest.123.3_suppl.339s.Peer-Reviewed Original ResearchConceptsChemokine receptor 2Vascular endothelial growth factorIL-13 inducesRegulation of inflammationGrowth factor-β1Endothelial growth factorOverexpression transgenic miceAsthma pathogenesisMurine airwaysKey cytokineInterleukin-13Receptor 2Factor-β1Transgenic miceIL-11Transgenic modelingLungGrowth factorPhenotypic alterationsGenetic targetsAirwayInflammationInterleukinStudy resultsCytokines
2001
Airway Inflammation and Remodeling in Asthma
ZHU Z, LEE C, ZHENG T, CHUPP G, WANG J, HOMER R, NOBLE P, HAMID Q, ELIAS J. Airway Inflammation and Remodeling in Asthma. American Journal Of Respiratory And Critical Care Medicine 2001, 164: s67-s70. PMID: 11734470, DOI: 10.1164/ajrccm.164.supplement_2.2106070.Peer-Reviewed Original ResearchConceptsAirway fibrosisAsthmatic airwaysIL-11IL-13Asthma-like inflammationExaggerated cytokine productionImportance of airwayMucin gene expressionHyaluronic acid accumulationAirway healingAsthmatic tissuesSevere airwayAirway inflammationAirway remodelingAsthmatic subjectsSubepithelial fibrosisAsthma phenotypesCytokine productionMurine airwaysMucous metaplasiaAirwayTransgenic miceNatural historyInterleukin-11FibrosisIL-4 Promotes Airway Eosinophilia by Suppressing IFN-γ Production: Defining a Novel Role for IFN-γ in the Regulation of Allergic Airway Inflammation
Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 Promotes Airway Eosinophilia by Suppressing IFN-γ Production: Defining a Novel Role for IFN-γ in the Regulation of Allergic Airway Inflammation. The Journal Of Immunology 2001, 166: 2760-2767. PMID: 11160342, DOI: 10.4049/jimmunol.166.4.2760.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, IntranasalAdoptive TransferAnimalsBone Marrow CellsBone Marrow TransplantationBronchiCell MovementDown-RegulationEosinophilsFemaleHematopoietic Stem CellsInflammationInterferon-gammaInterleukin-13Interleukin-4Interleukin-5MaleMiceMice, Inbred BALB CMice, KnockoutMice, TransgenicOvalbuminPulmonary EosinophiliaReceptors, InterferonRespiratory HypersensitivityTh2 CellsUp-RegulationConceptsAirway eosinophiliaIL-4IFN-gammaTh2 cellsAirway eosinophilsIL-5Allergic airway inflammationIFN-γ productionTh2 cell generationAirway inflammationEosinophilic inflammationLung eosinophiliaLung parenchymalTh2 cytokinesIntranasal administrationRespiratory tractLung tissueCounterregulatory effectsEosinophiliaCell transferEosinophilsHemopoietic cellsInflammationAirwayIFN
2000
CONSEQUENCES OF LONG-TERM INFLAMMATION Airway Remodeling
Homer R, Elias J. CONSEQUENCES OF LONG-TERM INFLAMMATION Airway Remodeling. Clinics In Chest Medicine 2000, 21: 331-343. PMID: 10907592, DOI: 10.1016/s0272-5231(05)70270-7.Peer-Reviewed Original ResearchConceptsAirway remodelingAirway chronic inflammationEffect of therapyAirway inflammationAsthmatic patientsAppropriate therapyChronic inflammationClinical manifestationsSmooth muscleCollagen depositionExperimental modelMucus glandsBiologic dataRemodelingAirwayInflammationTherapyAsthmaticsAsthmaPatientsNoncollagenous matrix
1997
Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.
Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.Peer-Reviewed Original ResearchConceptsHuman bronchial biopsiesHuman lung tissueExposure-disease relationshipsAirway eosinophilsAirway histologyEpithelial exposureMethacholine challengeBronchial biopsiesEndobronchial biopsyInflammatory changesClinical featuresAirway biopsiesIsocyanate asthmaLung tissueT cellsImmunohistochemical stainingAsthmaBiopsyExposure patternsBronchoscopyExposureAirwayPatientsEosinophilsHistology