2012
Semaphorin 7a+ Regulatory T Cells Are Associated with Progressive Idiopathic Pulmonary Fibrosis and Are Implicated in Transforming Growth Factor-β1–induced Pulmonary Fibrosis
Reilkoff RA, Peng H, Murray LA, Peng X, Russell T, Montgomery R, Feghali-Bostwick C, Shaw A, Homer RJ, Gulati M, Mathur A, Elias JA, Herzog EL. Semaphorin 7a+ Regulatory T Cells Are Associated with Progressive Idiopathic Pulmonary Fibrosis and Are Implicated in Transforming Growth Factor-β1–induced Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2012, 187: 180-188. PMID: 23220917, PMCID: PMC3570653, DOI: 10.1164/rccm.201206-1109oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisRegulatory T cellsProgressive idiopathic pulmonary fibrosisSEMA 7ATGF-β1Pulmonary fibrosisLung fibrosisT cellsMurine lungIL-10Bone marrow-derived cellsAdoptive transfer approachT-cell mediatorsMarrow-derived cellsTransforming Growth Factor-β1Murine lung fibrosisGrowth factor-β1Lung CD4Adoptive transferIL-17AIL-4Disease progressionSemaphorin 7ACD4Mouse model
2004
Regulation of pulmonary fibrosis by chemokine receptor CXCR3
Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. Journal Of Clinical Investigation 2004, 114: 291-299. PMID: 15254596, PMCID: PMC449741, DOI: 10.1172/jci16861.Peer-Reviewed Original ResearchConceptsCXC chemokine receptor 3Lung NK cellsCXCR3-deficient miceIFN-gamma productionLung injuryIFN-gammaEnhanced fibrosisNK cellsWT miceChemokine receptors CXC chemokine receptor 3Chemokine MIG/CXCL9Endogenous IFN-gamma productionI-TAC/CXCL11IP-10/CXCL10Inflammatory cell recruitmentProgressive interstitial fibrosisChemokine receptor 3Exogenous IFN-gammaExpression of CXCL10MIG/CXCL9CXCR3 deficiencyAdoptive transferPulmonary injuryLymph nodesPulmonary fibrosis