2020
National Survey of Pediatric Intestinal Rehabilitation Programs in the United States
Park CJ, Shaughnessy MP, Zhang L, Armenia SJ, Caty MG, Cowles RA. National Survey of Pediatric Intestinal Rehabilitation Programs in the United States. Journal Of Parenteral And Enteral Nutrition 2020, 45: 1249-1258. PMID: 32797633, DOI: 10.1002/jpen.1997.Peer-Reviewed Original ResearchConceptsPediatric intestinal rehabilitation programIntestinal rehabilitation programPIR programRehabilitation programChildren's Hospital AssociationHospital AssociationQualtrics online survey softwareIntestinal failureReferral centerPrimary carePatient outcomesImproved outcomesNutrition servicesResponse rateOnline survey softwareSurgeryMajority of programsGastroenterologyNursingFurther studiesNational surveySocial work supportSurvey softwareDedicated timeOutcomes
2019
Serum Citrulline Levels Exhibit Circadian Variation and Fluctuations in Relation to Food Intake in Mice
Park CJ, Shaughnessy MP, Armenia SJ, Cowles RA. Serum Citrulline Levels Exhibit Circadian Variation and Fluctuations in Relation to Food Intake in Mice. Gastroenterology Research 2019, 12: 88-92. PMID: 31019618, PMCID: PMC6469904, DOI: 10.14740/gr1146.Peer-Reviewed Original ResearchSerum citrulline levelsCitrulline levelsFood intakeSmall intestineCircadian variationFunctional intestinal massSmall bowel massPlasma citrulline levelsUse Committee guidelinesBowel massEnteral autonomySerum citrullineIntestinal failureEnterocyte massC57BL/6 micePrognostic valueFed micePlasma citrullineBlood drawIntestinal massNonessential amino acidsInstitutional Animal CareSimple biomarkerAnimal modelsVillus heightPotentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine
Park CJ, Armenia SJ, Shaughnessy MP, Greig CJ, Cowles RA. Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine. Journal Of Pediatric Surgery 2019, 54: 1245-1249. PMID: 30879746, DOI: 10.1016/j.jpedsurg.2019.02.027.Peer-Reviewed Original ResearchConceptsPotentiation of serotoninSmall intestineMucosal growthLipid absorptionSmall intestinal mucosal growthMucosal growth factorsSerotonin reuptake transporterSERT knockout miceDistal small intestineIntestinal mucosal growthCrypt cell proliferationT-testMucosal surface areaMurine small intestineStudent's t-testEnteric serotoninIntestinal failureIntestinal adaptationReuptake transporterDeficient miceWT animalsIntestinal homeostasisFatty acid analogueCrypt depthVillus height
2018
Retracing our STEPs: Four decades of progress in intestinal lengthening procedures for short bowel syndrome
Greig CJ, Oh PS, Gross ER, Cowles RA. Retracing our STEPs: Four decades of progress in intestinal lengthening procedures for short bowel syndrome. The American Journal Of Surgery 2018, 217: 772-782. PMID: 30514435, DOI: 10.1016/j.amjsurg.2018.11.025.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsShort bowel syndromeBowel syndromeReversed intestinal segmentInnovative new treatmentsBowel dilationIntestinal rehabilitationIntestinal failureBowel lengthSurgical managementBacterial overgrowthIntestinal adaptationColonic transpositionPatient outcomesSurgical techniqueLengthening surgeryIntestinal segmentsArtificial valvesNew treatmentsSyndromeCare paradigmPoor motilityBirthOutcomesTransit timeLong term