2007
Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor–β1‐mediated regulatory abnormalities including up‐regulation of C‐Myc and MTA1
Kidd M, Modlin IM, Pfragner R, Eick GN, Champaneria MC, Chan AK, Camp RL, Mane SM. Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor–β1‐mediated regulatory abnormalities including up‐regulation of C‐Myc and MTA1. Cancer 2007, 109: 2420-2431. PMID: 17469181, DOI: 10.1002/cncr.22725.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCadherinsCarcinoid TumorCell ProliferationCells, CulturedCyclin-Dependent Kinase Inhibitor p21Enterochromaffin CellsGene Expression Regulation, NeoplasticHistone DeacetylasesHumansIntestinal NeoplasmsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationProto-Oncogene Proteins c-mycRepressor ProteinsSignal TransductionSmad ProteinsTrans-ActivatorsTransforming Growth Factor beta1Tumor Cells, CulturedUp-RegulationConceptsEffects of TGFbeta1Normal EC cellsC-MycDownstream targetsEC cellsSmad2 phosphorylationE-cadherinCell proliferationEC cell proliferationProtein expressionGrowth regulatory mechanismsCandidate downstream targetsTranscriptional networksC-Myc pathwayC-myc transcriptsGrowth promotionCytostatic programGene responsesEC cell linesRegulatory mechanismsTranscript expressionTranscriptsNuclear translocationTumor cellsMTA1
2005
Automated Quantitative Analysis of E-Cadherin Expression in Lymph Node Metastases Is Predictive of Survival in Invasive Ductal Breast Cancer
Harigopal M, Berger AJ, Camp RL, Rimm DL, Kluger HM. Automated Quantitative Analysis of E-Cadherin Expression in Lymph Node Metastases Is Predictive of Survival in Invasive Ductal Breast Cancer. Clinical Cancer Research 2005, 11: 4083-4089. PMID: 15930343, DOI: 10.1158/1078-0432.ccr-04-2191.Peer-Reviewed Original ResearchConceptsE-cadherin expressionLymph node metastasisNodal metastasisBreast cancerImproved survivalNode metastasisTissue microarrayNode-positive breast cancerInvasive ductal breast cancerHER2/neu statusAnti-invasive roleInvasive ductal tumorsNode-positive patientsDuctal breast cancerSubset of patientsGood prognostic markerAggressive tumor behaviorStrong E-cadherin expressionHigh E-cadherin expressionCy5-conjugated antibodiesDuctal tumorsMetastatic sitesPrognostic valueTumor sizePrimary tumor