Safety and Efficacy of Nipocalimab in Patients With Generalized Myasthenia Gravis
Antozzi C, Guptill J, Bril V, Gamez J, Meuth S, Nowak R, Quan D, Sevilla T, Jouvin M, Jin J, Karcher K, Ramchandren S, Sun H, Ling L, Zhu Y, Arroyo S, Group F. Safety and Efficacy of Nipocalimab in Patients With Generalized Myasthenia Gravis. Neurology 2023, 102: e207937. PMID: 38165333, PMCID: PMC10962909, DOI: 10.1212/wnl.0000000000207937.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAntibodies, MonoclonalAutoantibodiesHumansMyasthenia GravisPatientsConceptsTreatment-emergent adverse eventsGeneralized myasthenia gravisSignificant dose responseAdverse eventsMG-ADLDay 57Myasthenia gravisDose responseMyasthenia Gravis ActivitiesPrimary safety endpointPrimary efficacy endpointSerious adverse eventsPhase 2 studyReceptor monoclonal antibodyDaily living (IADL) total scoreClinical trial registrationMG-ADL scoreDose-dependent reductionEudraCT numberQ2W groupEfficacy endpointPlacebo groupSafety endpointCare therapyReceptor autoantibodiesAddressing Outcome Measure Variability in Myasthenia Gravis Clinical Trials
Guptill J, Benatar M, Granit V, Habib A, Howard J, Barnett-Tapia C, Nowak R, Lee I, Ruzhansky K, Dimachkie M, Cutter G, Kaminski H, Group F. Addressing Outcome Measure Variability in Myasthenia Gravis Clinical Trials. Neurology 2023, 101: 442-451. PMID: 37076302, PMCID: PMC10491448, DOI: 10.1212/wnl.0000000000207278.Peer-Reviewed Original ResearchActivities of Daily LivingClinical Trials as TopicHumansMyasthenia GravisOutcome Assessment, Health CareQuality of Life