1998
Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide
Kapurniotu A, Bernhagen J, Greenfield N, Al‐Abed Y, Teichberg S, Frank R, Voelter W, Bucala R. Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide. The FEBS Journal 1998, 251: 208-216. PMID: 9492286, DOI: 10.1046/j.1432-1327.1998.2510208.x.Peer-Reviewed Original ResearchConceptsAmyloid formationIslet amyloid polypeptidePre-formed aggregatesAdvanced glycosylation end productsIAPP amyloid formationAlzheimer's disease amyloid peptideCircular dichroism spectropolarimetryNucleation-dependent polymerization mechanismBeta-sheet conformationIAPP aggregationBiophysical techniquesIAPP aggregatesHigh molecular massFormation of amyloidAmyloid structuresGreen-gold birefringenceProtein amino groupsCharacteristic fibrillar structureIslet amyloid formationSeedsFibrillar amyloid structuresGlycosylationPolymerization mechanismNon-enzymatic additionPeptide aggregation
1996
Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗)
Al-Abed Y, Bucala R, Liebich H, Voelter W. Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗). Journal Of Biological Chemistry 1996, 271: 2892-2896. PMID: 8621676, DOI: 10.1074/jbc.271.6.2892.Peer-Reviewed Original ResearchConceptsChemical ionization mass spectroscopyGas chromatography-mass spectrometry analysisIonization mass spectroscopyChromatography-mass spectrometry analysisOxidation product 4Acid side chainsUnsaturated fatty acyl groupsTransition metalsFatty acid side chainsHead groupsMass spectroscopySide chainsProduct 4Chemical basisCovalent additionFatty acyl groupsFree radical generating systemOxidationRadical generating systemSpectrometry analysisAcyl groupsMajor compoundsTissue LDL receptorsHigh affinityOxidative modification