2000
Tumor growth-promoting properties of macrophage migration inhibitory factor (MIF)
Mitchell R, Bucala R. Tumor growth-promoting properties of macrophage migration inhibitory factor (MIF). Seminars In Cancer Biology 2000, 10: 359-366. PMID: 11100884, DOI: 10.1006/scbi.2000.0328.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCyclic AMP-Dependent Protein KinasesGenes, p53HumansMacrophage Migration-Inhibitory FactorsMitogen-Activated Protein KinasesNeoplasmsNeovascularization, PathologicConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorPotent pro-inflammatory cytokinePro-inflammatory cytokinesInflammatory responseTumor progressionTumor angiogenesisTumor suppressor activitySuppressor activityCell proliferationRecent studiesGrowth-promoting propertiesCytokinesNeoplasiaMultiple aspectsProgression
1999
Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF) REGULATORY ROLE IN CELL PROLIFERATION AND GLUCOCORTICOID ACTION*
Mitchell R, Metz C, Peng T, Bucala R. Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF) REGULATORY ROLE IN CELL PROLIFERATION AND GLUCOCORTICOID ACTION*. Journal Of Biological Chemistry 1999, 274: 18100-18106. PMID: 10364264, DOI: 10.1074/jbc.274.25.18100.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorPhospholipase A2 activityGlucocorticoid actionRole of MIFRecombinant macrophage migration inhibitory factorMitogen-activated protein kinaseImportant pro-inflammatory mediatorsA2 activityCytosolic phospholipase A2 activityPro-inflammatory mediatorsMigration inhibitory factorPro-inflammatory stimuliImmune cell activationCytoplasmic phospholipase A2Phospholipase A2 activationArachidonic acid releaseGlucocorticoid suppressionERK-dependent pathwayMIF actionInflammatory propertiesInflammatory responseExtracellular signal-regulated mitogen-activated protein kinaseCell activationInhibitory factorA2 activation