2020
A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection
Johnson RM, Olivares-Strank N, Peng G. A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection. The Journal Of Infectious Diseases 2020, 221: 1895-1906. PMID: 31899500, PMCID: PMC7213565, DOI: 10.1093/infdis/jiz685.Peer-Reviewed Original ResearchConceptsGenital tract infectionCD8 T cellsT cell clonesChlamydia muridarum Genital Tract InfectionMHC class IIT cellsTract infectionsClass IIClass IAntigen-specific CD8 T cellsChlamydia genital tract infectionCD8 T cell clonesCD4 T cell numbersMajor histocompatibility complex class IAdoptive transfer studiesT cell numbersT cell responsesHistocompatibility complex class IComplex class IBacterial clearanceIL-13IL-5ImmunopathologyIntracellular pathogensInfection
2014
An atypical CD8 T‐cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin‐13
Johnson RM, Kerr MS, Slaven JE. An atypical CD8 T‐cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin‐13. Immunology 2014, 142: 248-257. PMID: 24428415, PMCID: PMC4008232, DOI: 10.1111/imm.12248.Peer-Reviewed Original ResearchConceptsGenital tract infectionCD8 T cellsCD8 T cell responsesCD8 T cell clonesT cell responsesTract infectionsT cell clonesT cellsProtective immunityInterleukin-13T helper type 1 cell responsesC. muridarum genital tract infectionChlamydia muridarum Genital Tract InfectionMHC class Ia moleculesCD4 T cellsRole of TNFAntigen-presenting cellsTumor necrosis factorReproductive tract epitheliumClass Ia moleculesCD8 clonesCD8 levelsChlamydia replicationNaive splenocytesIntracellular bacterial pathogen
2012
PmpG303-311, a Protective Vaccine Epitope That Elicits Persistent Cellular Immune Responses in Chlamydia muridarum-Immune Mice
Johnson RM, Yu H, Kerr MS, Slaven JE, Karunakaran KP, Brunham RC. PmpG303-311, a Protective Vaccine Epitope That Elicits Persistent Cellular Immune Responses in Chlamydia muridarum-Immune Mice. Infection And Immunity 2012, 80: 2204-2211. PMID: 22431650, PMCID: PMC3370596, DOI: 10.1128/iai.06339-11.Peer-Reviewed Original ResearchConceptsGenital tract infectionAntigen-presenting cellsT cell clonesTract infectionsMonths postinfectionImmune responseChlamydia muridarum Genital Tract InfectionProtective CD4 T cell responsesVaccine developmentPrimary genital tract infectionTh1 T cell clonesCD4 T cell responsesCD4 T-cell clonesSplenic antigen-presenting cellsAntigen-presenting cell populationsCell clonesCD4 T cellsT cell responsesCellular immune responsesProtective immune responsePromising vaccine candidateImmune C57BL/6 miceInfected epithelial cellsIrradiated splenocytesUrogenital chlamydia