2024
Risk vs. Reward: Impact of Kidney Biopsies on the Management of Critically Ill Patients
Llama A, Sadarangani S, Moledina D, Luciano R. Risk vs. Reward: Impact of Kidney Biopsies on the Management of Critically Ill Patients. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024dd7bnz12. DOI: 10.1681/asn.2024dd7bnz12.Peer-Reviewed Original ResearchAdjudication of Kidney Biopsy Histopathology to Establish Consensus Diagnosis of Tubulointerstitial Nephritis
Sadarangani S, Shaw M, Moeckel G, Kumar D, Kuperman M, Rosenberg A, Luciano R, Menez S, Perazella M, Wilson F, Makhijani A, Shelton K, Parikh C, Moledina D. Adjudication of Kidney Biopsy Histopathology to Establish Consensus Diagnosis of Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20241qexcb21. DOI: 10.1681/asn.20241qexcb21.Peer-Reviewed Original ResearchThe Case | An active injection drug user with a skin rash and kidney failure
Aron A, Luciano R. The Case | An active injection drug user with a skin rash and kidney failure. Kidney International 2024, 105: 1327-1328. PMID: 38777409, DOI: 10.1016/j.kint.2024.03.009.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original ResearchRationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized controlled trialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-controlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2023
Diffuse Alveolar Hemorrhage Presenting in IgA Nephropathy
Jobson C, Luciano R, Shirali A, Malvar G. Diffuse Alveolar Hemorrhage Presenting in IgA Nephropathy. Journal Of The American Society Of Nephrology 2023, 34: 1119-1119. DOI: 10.1681/asn.20233411s11119a.Peer-Reviewed Original ResearchGuillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management
Mehta P, Luciano R, Aklilu A, Malvar G. Guillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management. Journal Of The American Society Of Nephrology 2023, 34: 277-277. DOI: 10.1681/asn.20233411s1277a.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2022
Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity
Qian L, Menez S, Hu D, Weinstein J, Melchinger H, Thiessen-Philbrook H, Luciano R, Turner J, Perazella M, Villalobos C, Shaw M, Wilson F, Parikh C, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity. Kidney360 2022, 4: 98-101. PMID: 36700910, PMCID: PMC10101611, DOI: 10.34067/kid.0006602022.Peer-Reviewed Original ResearchAA Amyloidosis Presenting With Renal Amyloidoma
Gunasekaran D, Luciano R. AA Amyloidosis Presenting With Renal Amyloidoma. Journal Of The American Society Of Nephrology 2022, 33: 167-168. DOI: 10.1681/asn.20223311s1167e.Peer-Reviewed Original ResearchPeritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON
Luciano R. Peritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON. Kidney360 2022, 4: 138-140. PMID: 36821605, PMCID: PMC10103267, DOI: 10.34067/kid.0007822021.Peer-Reviewed Original ResearchInfiltrative Disease of the Tubulointerstitium
Aklilu A, Luciano R. Infiltrative Disease of the Tubulointerstitium. 2022, 231-241. DOI: 10.1007/978-3-030-93438-5_18.Peer-Reviewed Original ResearchInfiltrative diseasePlasma cell disordersRenal cell carcinomaRenal tubular cellsWhite blood cellsCancer-targeted therapyKidney injuryPrimary malignancySecondary inflammationTubular damageTubulointerstitial nephritisBronchogenic carcinomaInfiltrative lesionsLymphoproliferative disordersCell carcinomaMetastatic spreadBreast cancerPrimary involvementNormal kidneySolid cancersCell disordersTubular cellsTubular lumenBlood cellsDisease
2021
Lysozyme nephropathy: A rare and reversible cause of acute kidney injury in chronic myelomonocytic leukemia
Donati A, Luciano R, Shirali A. Lysozyme nephropathy: A rare and reversible cause of acute kidney injury in chronic myelomonocytic leukemia. Journal Of Onco-Nephrology 2021, 5: 120-121. DOI: 10.1177/23993693211026926.Peer-Reviewed Case Reports and Technical Notes
2020
37 Kidney disease in leukemia
LUCIANO R. 37 Kidney disease in leukemia. 2020, 337-346.e1. DOI: 10.1016/b978-0-323-54945-5.00046-1.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryDevelopment of AKIPrerenal acute kidney injuryAcute tubular necrosisSolid organ malignanciesAcid-base abnormalitiesBone marrow cellsUnderlying malignancyRenovascular diseaseOrgan malignanciesTubular necrosisParenchymal infiltrationSecondary complicationsKidney diseaseCommon cancerHematologic malignanciesDisease manifestationsLeukemiaMarrow cellsMalignancyInjuryDiseaseKidneyBroad spectrum38 Kidney disease in lymphoma
LUCIANO R. 38 Kidney disease in lymphoma. 2020, 347-354.e1. DOI: 10.1016/b978-0-323-54945-5.00047-3.Peer-Reviewed Original ResearchKidney injuryPrerenal acute kidney injuryAcute kidney injuryAcute tubular necrosisNon-Hodgkin lymphomaTreatment of lymphomaAcid-base abnormalitiesComorbid illnessesRenovascular diseaseTubular necrosisLymph nodesParenchymal infiltrationKidney manifestationsProgressive injuryKidney diseaseHematologic malignanciesLymph tissueLymphoid cellsSide effectsLymphomaAbnormal proliferationInjuryPatientsDiseaseMalignancy
2019
Medication-Associated Glomerular Disease
Tucker B, Luciano R. Medication-Associated Glomerular Disease. 2019, 735-772. DOI: 10.1007/978-3-319-49379-4_46.Peer-Reviewed Original ResearchGlomerular diseaseTubule-interstitial diseaseMinimal change diseaseFocal segmental glomerulosclerosisKidney injuryThrombotic microangiopathyAcute hemodynamicsCrystalline nephropathyChange diseaseHistologic patternSegmental glomerulosclerosisAdditional interventionsMedicationsDisease severitySpecific drugsDiseaseInjuryDrugsVasculitisHematuriaMicroangiopathyProteinuriaDiscontinuationGlomerulonephritisNephropathy
2018
NESVS20. Treatment of Superior Vena Cava Syndrome with Kissing Brachiocephalic Stents and Exchange of Pacemaker Leads
Chaar C, Gholitabar N, Rezek I, Luciano R, Clancy J. NESVS20. Treatment of Superior Vena Cava Syndrome with Kissing Brachiocephalic Stents and Exchange of Pacemaker Leads. Journal Of Vascular Surgery 2018, 68: e107. DOI: 10.1016/j.jvs.2018.06.124.Peer-Reviewed Original ResearchDrug-Induced Acute Kidney Injury
Luciano R, Perazella M. Drug-Induced Acute Kidney Injury. 2018, 145-163. DOI: 10.1007/978-1-4939-8628-6_9.Peer-Reviewed Original ResearchDrug-induced acute kidney injuryAcute kidney injuryKidney injuryAcute tubular injury/necrosisAcute interstitial nephritisFocal segmental glomerulosclerosisDrugs/substancesOsmotic nephropathyRisk patientsInterstitial nephritisKidney functionPrescribed medicationsSegmental glomerulosclerosisEarly identificationRenal compartmentsInjuryHarmful drugsTherapeutic agentsAdverse effectsCommon formDrugsMedicationsKidneyCommon problemDiagnostic agentsTreatment of Superior Vena Cava Syndrome With Kissing Brachiocephalic Stents and Exchange of Pacemaker Leads
Chaar C, Gholitabar N, Rezek I, Luciano R, Clancy J. Treatment of Superior Vena Cava Syndrome With Kissing Brachiocephalic Stents and Exchange of Pacemaker Leads. Journal Of Vascular Surgery 2018, 68: e16. DOI: 10.1016/j.jvs.2018.05.061.Peer-Reviewed Original Research33 Acute Interstitial Nephritis
Brewster U, Luciano R. 33 Acute Interstitial Nephritis. 2018, 320-325. DOI: 10.1016/b978-0-323-47794-9.00033-0.Peer-Reviewed Original ResearchAcute interstitial nephritisInterstitial nephritisCellular interstitial infiltratesForm of AKITriad of feverSetting of infectionUrine of patientsOccasional plasma cellsRenal tubular cellsKidney injuryMedication exposureSterile pyuriaCulprit medicationKidney biopsyMild proteinuriaInterstitial infiltratesSystemic diseaseAutoimmune diseasesDefinitive diagnosisCommon causePlasma cellsImmune responseUrine sedimentTubular cellsRapid treatment