Dextromethorphan Mediated Bitter Taste Receptor Activation in the Pulmonary Circuit Causes Vasoconstriction
Upadhyaya J, Singh N, Sikarwar A, Chakraborty R, Pydi S, Bhullar R, Dakshinamurti S, Chelikani P. Dextromethorphan Mediated Bitter Taste Receptor Activation in the Pulmonary Circuit Causes Vasoconstriction. PLOS ONE 2014, 9: e110373. PMID: 25340739, PMCID: PMC4207743, DOI: 10.1371/journal.pone.0110373.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDextromethorphanFluorescent Antibody TechniqueGene Expression RegulationGene Knockdown TechniquesHumansIn Vitro TechniquesInositol 1,4,5-TrisphosphateLungMyocytes, Smooth MuscleMyographyMyosin Light ChainsPhosphorylationPulmonary ArteryReceptors, G-Protein-CoupledReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSuperoxidesSus scrofaTasteVasoconstrictionConceptsPulmonary artery smooth muscle cellsArtery smooth muscle cellsHuman pulmonary artery smooth muscle cellsSmooth muscle cellsAirway ringsMuscle cellsVascular tonePulmonary circuitCalcium responseHuman airway smooth muscle cellsAirway smooth muscle cellsExpression of T2RsPulmonary vascular toneBitter taste receptor activationTaste receptor activationEx vivo studyVasoconstrictor responsesBitter taste receptorsMyographic studiesMuscle relaxationReceptor activationDextromethorphanSpecific shRNART-PCRVivo studies