2023
Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Park D, Wu Y, Wang X, Gowrishankar S, Baublis A, De Camilli P. Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates. Nature Communications 2023, 14: 455. PMID: 36709207, PMCID: PMC9884207, DOI: 10.1038/s41467-023-36081-3.Peer-Reviewed Original ResearchConceptsMembrane proteinsSV membrane proteinsVesicle membrane proteinEctopic expression systemSynaptic vesicle proteinsSynaptic vesicle clustersSV proteinsVesicle proteinsEctopic expressionExpression systemVesicle clustersSynapsinProteinLiquid-like propertiesVesiclesDistinct classesDual roleSynapsin 1FibroblastsATG9ASynapsesExpressionDistinct phasesNerve terminalsClusters
2022
SHIP164 is a chorein motif lipid transfer protein that controls endosome–Golgi membrane traffic
Hanna MG, Suen PH, Wu Y, Reinisch KM, De Camilli P. SHIP164 is a chorein motif lipid transfer protein that controls endosome–Golgi membrane traffic. Journal Of Cell Biology 2022, 221: e202111018. PMID: 35499567, PMCID: PMC9067936, DOI: 10.1083/jcb.202111018.Peer-Reviewed Original ResearchConceptsMannose-6-phosphate receptorCation-independent mannose-6-phosphate receptorMembrane contact sitesEarly endocytic pathwayGolgi membrane trafficLipid transfer proteinLipid transfer propertiesProtein-lipid ratioMembrane cargoMembrane trafficEndocytic membranesVesicular trafficRetrograde trafficEndocytic pathwayFunctional characterizationContact sitesMembranous organellesGolgi complexVesicle clustersCellular membranesTransfer proteinProteinLipid compositionOrganellesMembrane
2001
Glutamate regulates actin-based motility in axonal filopodia
Chang S, De Camilli P. Glutamate regulates actin-based motility in axonal filopodia. Nature Neuroscience 2001, 4: 787-793. PMID: 11477424, DOI: 10.1038/90489.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBridged Bicyclo Compounds, HeterocyclicCalciumCalcium ChannelsCell DifferentiationCell MovementCells, CulturedCentral Nervous SystemGlutamic AcidGreen Fluorescent ProteinsGrowth ConesHippocampusImmunohistochemistryLuminescent ProteinsNeuronal PlasticityPseudopodiaRatsReceptors, AMPAReceptors, N-Methyl-D-AspartateTau ProteinsThiazolesThiazolidinesConceptsAdult nervous systemGlutamate receptorsNervous systemAxonal filopodiaAMPA/kainate glutamate receptorsKainate glutamate receptorsEffects of glutamateIonotropic glutamate receptorsCNQX treatmentSynaptic vesicle clustersAxonal arborsAxonal branchesDendritic spinesExtracellular Ca2Neurotransmitter glutamateSynaptic formationSynaptic plasticityInhibitory effectGlutamateReceptorsVesicle clustersNMDASynaptogenesisSpine