2012
The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
Corlett PR, Fletcher PC. The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people. Neuropsychologia 2012, 50: 3612-3620. PMID: 23079501, PMCID: PMC3694307, DOI: 10.1016/j.neuropsychologia.2012.09.045.Peer-Reviewed Original ResearchConceptsHealthy peopleSymptoms of psychosisPsychotic illnessEarly psychosisHealthy individualsPsychosis showHealthy beliefsAdditional alterationsNeural markersNeural responsesSymptomsPsychosisNovel evidenceDelusional ideationDistressSchizotypal experiencesAlterationsPatientsPrevious observationsIllness
2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividuals
2006
Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC. Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis. JAMA Psychiatry 2006, 63: 611-621. PMID: 16754834, DOI: 10.1001/archpsyc.63.6.611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAssociation LearningBrief Psychiatric Rating ScaleCognition DisordersDelusionsDisease SusceptibilityDose-Response Relationship, DrugFemaleFrontal LobeHumansKetamineMagnetic Resonance ImagingMaleModels, TheoreticalPerceptual DisordersPlacebosProbabilityPsychiatric Status Rating ScalesPsychoses, Substance-InducedPsychotic DisordersConceptsDelusion formationPerceptual AberrationBrain activityError-dependent learningPharmacological functional magnetic resonanceAssociative learning taskFunctional magnetic resonance imagingAssociative learning processesDelusion-like beliefsFrontal cortical functionFunctional magnetic resonanceFull Scale IQUnderstanding of psychosisRight frontal cortexRight-handed volunteersNeurobiological accountsCognitive processesClinical Neuroscience InstituteFrontal activationAssociative learningFrontal responseBrain activationStructured Clinical InterviewLearning taskPsychotogenic effects
2004
On the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning
Fletcher P, Zafiris O, Frith C, Honey R, Corlett P, Zilles K, Fink G. On the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning. Cerebral Cortex 2004, 15: 1002-1015. PMID: 15537672, PMCID: PMC3838938, DOI: 10.1093/cercor/bhh201.Peer-Reviewed Original ResearchConceptsImplicit learningFunctional magnetic resonance imaging studyExplicit memory processesExpression of learningRight frontal activationLearning-related changesMedial temporal lobeMagnetic resonance imaging studyImplicit sequenceResonance imaging studyBrain basisFrontal activationNeural basisMemory processesSequence difficultyMotor sequenceBrain activityBehavioral experimentsTemporal lobeBehavioral effectsLearningExplicit attemptSubjective intentionAutomatic learningImaging studies