2011
Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings
Fox HC, Anderson GM, Tuit K, Hansen J, Kimmerling A, Siedlarz KM, Morgan PT, Sinha R. Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings. Alcohol Clinical And Experimental Research 2011, 36: 351-360. PMID: 21919922, PMCID: PMC3243763, DOI: 10.1111/j.1530-0277.2011.01628.x.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcoholismAnxietyBlood PressureCuesDiagnostic and Statistical Manual of Mental DisordersDouble-Blind MethodEmotionsFemaleHemodynamicsHumansHypothalamo-Hypophyseal SystemImaginationMalePituitary-Adrenal SystemPrazosinSecondary PreventionStress, PsychologicalConceptsCue-induced alcohol cravingNegative emotionsAlcohol-dependent individualsBlunted HPA responseAlcohol cravingAlcohol cuesStress dysregulationTreatment-seeking alcohol-dependent individualsCue-induced alcoholAlcohol cue exposureCue-Induced CravingImagery exposureBlood pressureHPA responseLower alcohol cravingCue exposureRelapse susceptibilityPreliminary efficacy studyEmotionsPrazosin groupPlacebo groupCravingCounterbalanced orderControl conditionAnxiety
2007
Sex Steroid Hormones, Stress Response, and Drug Craving in Cocaine-Dependent Women: Implications for Relapse Susceptibility
Sinha R, Fox H, Hong KI, Sofuoglu M, Morgan PT, Bergquist KT. Sex Steroid Hormones, Stress Response, and Drug Craving in Cocaine-Dependent Women: Implications for Relapse Susceptibility. Experimental And Clinical Psychopharmacology 2007, 15: 445-452. PMID: 17924778, DOI: 10.1037/1064-1297.15.5.445.Peer-Reviewed Original ResearchConceptsSex steroid hormonesCocaine-dependent womenSteroid hormonesProgesterone groupDrug cravingProgesterone levelsCocaine cravingCue-induced cocaine cravingDiastolic blood pressure levelsDrug cue-induced cravingCue-induced anxietyBlood pressure levelsBlood pressure responseRelapse susceptibilityEffect of progesteroneLow progesterone levelsHigh progesterone groupLow progesterone groupHigh progesterone levelsStress-induced cravingCue-induced cravingSex differencesCue-induced cocaineProgesterone effectsCardiovascular responses