2014
Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals
Fox HC, Morgan PT, Sinha R. Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals. Neuropsychopharmacology 2014, 39: 1527-1537. PMID: 24395021, PMCID: PMC3988558, DOI: 10.1038/npp.2014.1.Peer-Reviewed Original ResearchConceptsCocaine use disorderImagery conditionNegative emotionsDrug cravingUse disordersCocaine-dependent individualsCocaine-dependent malesCocaine-dependent menSex differencesGuanfacine's effectsDrug cuesImagery exposureNegative moodSystolic blood pressureStress arousalNicotine cravingAlcohol cravingCounterbalanced orderCravingCocaine cravingAnxietyCocaine addictionEmotionsRecovery time pointsGuanfacine
2007
Sex Steroid Hormones, Stress Response, and Drug Craving in Cocaine-Dependent Women: Implications for Relapse Susceptibility
Sinha R, Fox H, Hong KI, Sofuoglu M, Morgan PT, Bergquist KT. Sex Steroid Hormones, Stress Response, and Drug Craving in Cocaine-Dependent Women: Implications for Relapse Susceptibility. Experimental And Clinical Psychopharmacology 2007, 15: 445-452. PMID: 17924778, DOI: 10.1037/1064-1297.15.5.445.Peer-Reviewed Original ResearchConceptsSex steroid hormonesCocaine-dependent womenSteroid hormonesProgesterone groupDrug cravingProgesterone levelsCocaine cravingCue-induced cocaine cravingDiastolic blood pressure levelsDrug cue-induced cravingCue-induced anxietyBlood pressure levelsBlood pressure responseRelapse susceptibilityEffect of progesteroneLow progesterone levelsHigh progesterone groupLow progesterone groupHigh progesterone levelsStress-induced cravingCue-induced cravingSex differencesCue-induced cocaineProgesterone effectsCardiovascular responsesAltered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
Fox HC, Hong KA, Paliwal P, Morgan PT, Sinha R. Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females. Psychopharmacology 2007, 195: 527-536. PMID: 17891383, PMCID: PMC2746368, DOI: 10.1007/s00213-007-0936-3.Peer-Reviewed Original ResearchConceptsMenstrual cycleSex hormonesHealthy femalesEstradiol/progesterone ratioSteroid hormonesFirst monthChronic cocaine abuseSex steroid hormonesLevels of cortisolMood rating scalesStress steroid hormonesDrug-seeking behaviorProgesterone ratioHealthy controlsInpatient treatmentObjectivesThe current studyEvidence of alterationsBrain stressCocaine cravingCocaine abuseSalivary samplesCocaine abstinenceCocaine dependenceCocaine reinforcementCocaine patients