2024
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses
Yang Y, Treger R, Hernandez-Bird J, Lu P, Mao T, Iwasaki A. A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses. Science Immunology 2024, 9: eadd6608. PMID: 39514636, DOI: 10.1126/sciimmunol.add6608.Peer-Reviewed Original ResearchConceptsB-1 cellsB cell-deficient miceEndogenous retrovirusesEnveloped virusesNatural IgM antibodiesGermline-encoded antibodiesNaive miceInnate antiviral mechanismsGenetic invadersB cellsVertebrate genomesNatural antibody repertoireRepertoire profilingSurface antigensInfectious endogenous retrovirusIgM antibodiesSelf-proteinsComplement pathwayAntibody repertoireAntibodiesMiceRetrovirusesVirusSensor stimulationGlycoprotein
2013
Follicular T‐helper cells: controlled localization and cellular interactions
Qi H, Chen X, Chu C, Lu P, Xu H, Yan J. Follicular T‐helper cells: controlled localization and cellular interactions. Immunology And Cell Biology 2013, 92: 28-33. PMID: 24145857, DOI: 10.1038/icb.2013.59.Peer-Reviewed Original ResearchConceptsB cell responsesGerminal centersTfh cellsEffective antibody-based vaccineFollicular T helper cellsDependent B cell responsesIsotype-switched antibodiesAntibody-based vaccinesCD4 T cellsT helper cellsHumoral autoimmunityHumoral protectionT cellsTranscriptional repressor Bcl-6Surface phenotypeSuch antibodiesBCL-6Microbial infectionsGC reactionAntibodiesCellsCellular interactionsCurrent understandingHigh levelsAutoimmunity