2003
Signaling Via the T Cell Receptor
Singer A, Jordan M, Judd B, Myung P, Newbrough S, Nichols K, Olenchock B, Peterson E, Wu J, Zhong X, Koretzky G. Signaling Via the T Cell Receptor. Science Signaling 2003, 2003 DOI: 10.1126/stke.2003.194.cm7.Peer-Reviewed Original ResearchRas-mitogen-activated protein kinaseSrc homology 2 domainPhospholipase C-γ1 activationT cell signal transductionProtein kinase C θCell signal transductionT cell activationT cell receptor engagementTranscription factor nuclear factorCell receptor engagementRas guanineSLP-76Cytoplasmic domainSignal transductionSrc familyProtein kinaseActivation motifCell activationDownstream targetsMAP pathwayCleavage of phosphatidylinositolNegative regulatorGene expressionProximal regulatorSecond messenger
2001
Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells
Allman D, Karnell F, Punt J, Bakkour S, Xu L, Myung P, Koretzky G, Pui J, Aster J, Pear W. Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells. Journal Of Experimental Medicine 2001, 194: 99-106. PMID: 11435476, PMCID: PMC2193437, DOI: 10.1084/jem.194.1.99.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowCell LineageDNA-Binding ProteinsHematopoietic Stem CellsHyaluronan ReceptorsLeukemia, T-CellMembrane ProteinsMiceMice, TransgenicReceptor, Notch1Receptors, Antigen, T-Cell, alpha-betaReceptors, Cell SurfaceReceptors, Interleukin-2Signal TransductionThymus GlandT-LymphocytesTranscription FactorsConceptsT lineage commitmentT cell developmentHematopoietic stem cellsLineage commitmentCell developmentSrc homology 2 domainPre-T cell receptorBone marrowT cell-specific signalsBM transferT cellsCell-specific signalsMultipotent progenitor cellsDouble-positive T cellsTCR-beta transgeneLeukocyte proteinBM cell populationsFunction of Notch1T-cell leukemiaLater time pointsCD3 epsilonActive Notch1Beta transgeneBM cellsCell leukemia