2012
RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses
Akirav EM, Preston-Hurlburt P, Garyu J, Henegariu O, Clynes R, Schmidt AM, Herold KC. RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses. PLOS ONE 2012, 7: e34698. PMID: 22509345, PMCID: PMC3324532, DOI: 10.1371/journal.pone.0034698.Peer-Reviewed Original ResearchConceptsHuman immune responseT cellsImmune responseHuman T cellsRAGE expressionAntigen-specific T cellsAdaptive human immune responsesAdaptive immune cellsSpecific T cellsHealthy control subjectsAdaptive immune responsesExpression of RAGELevels of RAGEInnate immune responseAdvanced glycation endproductsActivated T cellsT cell activationIL-17AGlucose controlControl subjectsIL-5Immune cellsGlycation endproductsCell activationPatients
1991
On the complexity of self
Rudensky A, Rath S, Preston-Hurlburt P, Murphy D, Janeway C. On the complexity of self. Nature 1991, 353: 660-662. PMID: 1656278, DOI: 10.1038/353660a0.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesSelf peptidesT cellsY-AeSelf MHC class II moleculesCD4 T cellsMajor histocompatibility complex moleculesMHC class IIMHC class II complexesHistocompatibility complex moleculesClass II complexesIntrathymic selectionSelf antigensIntrathymic developmentNovel MHCClass II