2014
The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma
Akirav EM, Henegariu O, Preston-Hurlburt P, Schmidt AM, Clynes R, Herold KC. The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma. PLOS ONE 2014, 9: e95678. PMID: 24759895, PMCID: PMC3997417, DOI: 10.1371/journal.pone.0095678.Peer-Reviewed Original ResearchConceptsAdaptive immune responsesT cell responsesEffects of RAGEGlycation end productsT cell activationT cellsImmune responseWT miceCellular infiltrationCell activationCell responsesBronchial alveolar lavage fluidAdvanced glycation end productsMediastinal lymph nodesT cell infiltrationIL-5 productionOT-II miceRAGE-deficient miceT cell subsetsAlveolar lavage fluidMultiplex bead analysisRole of RAGET cell proliferationDeficient T cellsT cell differentiation
2012
RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses
Akirav EM, Preston-Hurlburt P, Garyu J, Henegariu O, Clynes R, Schmidt AM, Herold KC. RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses. PLOS ONE 2012, 7: e34698. PMID: 22509345, PMCID: PMC3324532, DOI: 10.1371/journal.pone.0034698.Peer-Reviewed Original ResearchConceptsHuman immune responseT cellsImmune responseHuman T cellsRAGE expressionAntigen-specific T cellsAdaptive human immune responsesAdaptive immune cellsSpecific T cellsHealthy control subjectsAdaptive immune responsesExpression of RAGELevels of RAGEInnate immune responseAdvanced glycation endproductsActivated T cellsT cell activationIL-17AGlucose controlControl subjectsIL-5Immune cellsGlycation endproductsCell activationPatients