2019
Glymphatic System Function in Relation to Anesthesia and Sleep States
Benveniste H, Heerdt PM, Fontes M, Rothman DL, Volkow ND. Glymphatic System Function in Relation to Anesthesia and Sleep States. Anesthesia & Analgesia 2019, 128: 747-758. PMID: 30883420, DOI: 10.1213/ane.0000000000004069.Peer-Reviewed Original ResearchConceptsEye movement sleepGlymphatic systemMovement sleepNon-rapid eye movement sleepRapid eye movement (REM) sleepTight blood-brain barrierCentral nervous system tissueCerebral oxygen consumptionCritical care settingBlood-brain barrierGlymphatic system functionCentral nervous systemNervous system tissueCerebrospinal fluid flowAnesthetic regimensBrain glymphatic systemBrain parenchymaCognitive dysfunctionCare settingsNervous systemClinical explorationWaste clearanceWakefulness persistLymphatic systemKey anatomical components
2006
Hemodynamic Effects of Di-Sec-Butyl Phenol, an Anesthetic Substituted Phenol
Deau J, Heerdt PM, H.S. The A, Wang Q. Hemodynamic Effects of Di-Sec-Butyl Phenol, an Anesthetic Substituted Phenol. Pharmacology 2006, 76: 117-122. PMID: 16374073, DOI: 10.1159/000090501.Peer-Reviewed Original ResearchConceptsMean blood pressureBlood pressureHeart rateHemodynamic effectsSympathetic nervous systemAge-dependent elevationHuman neuroblastoma cell lineRelease of catecholaminesSH-SY5Y cellsNeuroblastoma cell linesGanglionic blockadeNorepinephrine releaseNervous systemControl valuesYoung rabbitsCell linesElderly rabbitsRabbitsHypnosisHexamethoniumBlockadeCatecholaminesDoseRelease