2024
The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats
Terreros G, Pérez M, Muñoz-LLancao P, D’Espessailles A, Martínez E, Dagnino-Subiabre A. The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats. Nutrients 2024, 16: 381. PMID: 38337665, PMCID: PMC10857380, DOI: 10.3390/nu16030381.Peer-Reviewed Original ResearchConceptsStressed ratsInfluence anxiety-like behaviorStress-induced dendritic atrophyVulnerability to chronic stressRat chowAnxiety-like behaviorChronically stressed ratsRestraint stress protocolNon-stressedLocomotor activitySpatial memoryY-mazeCognitive performanceHippocampal morphologyMale Sprague-Dawley ratsDendritic atrophyChronic stressPrepubertal male Sprague-Dawley ratsStress protocolNeuroprotective roleSprague-Dawley ratsDendritic lengthCA3 areaPyramidal neuronsBrain physiology
2018
Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability
Zamarbide M, Mossa A, Muñoz-Llancao P, Wilkinson M, Pond H, Oaks A, Manzini M. Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability. Biological Psychiatry 2018, 85: 760-768. PMID: 30732858, PMCID: PMC6474812, DOI: 10.1016/j.biopsych.2018.12.013.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive deficitsIntellectual disabilitySpectrum disorderNeurodevelopmental disordersMouse model of autismFemale miceRegulates cyclic adenosine monophosphateSpatial memory deficitsModel of autismPrevalence of neurodevelopmental disordersMale micePDE4D activityMale-specific mannerMemory deficitsSpatial memoryCyclic adenosine monophosphateIntracellular signalingBehavioral studiesMolecular deficitsAutismBehavioral differencesHippocampusCC2D1ADeficits
2015
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Muñoz-Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc'h F, Schmidt M, González-Billault C. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. Journal Of Neuroscience 2015, 35: 11315-11329. PMID: 26269639, PMCID: PMC6605123, DOI: 10.1523/jneurosci.3645-14.2015.Peer-Reviewed Original ResearchConceptsNeuronal polarityAcquisition of neuronal polarityAxon specificationGenetic manipulationRap1b activationExchange proteinGuanine exchange factorKnock-outEpac signalingRegulate neuronal polarityProtein kinase A.Axon determinationRap GTPasesWild-type neuronsExchange factorActivation of protein kinase A.Polarity defectsMouse neuronsRat hippocampal neuronsMessenger cAMPMolecular eventsEpacMature axonsCAMP-dependent mechanismPharmacological inhibition