2018
Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability
Zamarbide M, Mossa A, Muñoz-Llancao P, Wilkinson M, Pond H, Oaks A, Manzini M. Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability. Biological Psychiatry 2018, 85: 760-768. PMID: 30732858, PMCID: PMC6474812, DOI: 10.1016/j.biopsych.2018.12.013.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive deficitsIntellectual disabilitySpectrum disorderNeurodevelopmental disordersMouse model of autismFemale miceRegulates cyclic adenosine monophosphateSpatial memory deficitsModel of autismPrevalence of neurodevelopmental disordersMale micePDE4D activityMale-specific mannerMemory deficitsSpatial memoryCyclic adenosine monophosphateIntracellular signalingBehavioral studiesMolecular deficitsAutismBehavioral differencesHippocampusCC2D1ADeficits
2017
Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation
Muñoz‐Llancao P, de Gregorio C, Heras M, Meinohl C, Noorman K, Boddeke E, Cheng X, Lezoualc'h F, Schmidt M, Gonzalez‐Billault C. Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation. Cytoskeleton 2017, 74: 143-158. PMID: 28164467, DOI: 10.1002/cm.21355.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCyclic AMP-Dependent Protein KinasesHumansMicrotubule ProteinsNeuroblastomaSignal TransductionConceptsMicrotubule-regulating proteinsN1E-115 cellsMicrotubule-stabilizing factorsDifferentiation of N1E-115 neuroblastoma cellsPKA-AKAP interactionsMicrotubule-destabilizing proteinNeuroblastoma cellsEpac-dependent signalingFunctions of EPACDifferentiated neuroblastoma cellsInduce neuronal differentiationCAMP-dependent signalingN1E-115Analog of cyclic AMPN1E-115 neuroblastoma cellsIntracellular domainMicrotubule stabilityDb-cAMPCell biologyCell differentiationEpac activationNeuroblastoma differentiationNeuronal differentiationDifferentiated cellsNeuronal cells
2015
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Muñoz-Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc'h F, Schmidt M, González-Billault C. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. Journal Of Neuroscience 2015, 35: 11315-11329. PMID: 26269639, PMCID: PMC6605123, DOI: 10.1523/jneurosci.3645-14.2015.Peer-Reviewed Original ResearchConceptsNeuronal polarityAcquisition of neuronal polarityAxon specificationGenetic manipulationRap1b activationExchange proteinGuanine exchange factorKnock-outEpac signalingRegulate neuronal polarityProtein kinase A.Axon determinationRap GTPasesWild-type neuronsExchange factorActivation of protein kinase A.Polarity defectsMouse neuronsRat hippocampal neuronsMessenger cAMPMolecular eventsEpacMature axonsCAMP-dependent mechanismPharmacological inhibition
2014
A‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
Poppinga W, Muñoz‐Llancao P, González‐Billault C, Schmidt M. A‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases. British Journal Of Pharmacology 2014, 171: 5603-5623. PMID: 25132049, PMCID: PMC4290705, DOI: 10.1111/bph.12882.Peer-Reviewed Original ResearchConceptsA-kinase anchoring proteinsCAMP compartmentationCAMP effector proteinsCompartmentalized cAMP signalingGs protein-coupled receptorsCellular content of cAMPEffector proteinsCompartmentalization of cAMPAnchoring proteinsCAMP compartmentCellular functionsContent of cAMPA-kinaseCAMP signalingProtein-coupled receptorsActivation of PKAObstructive pulmonary diseaseMessenger cAMPExchange proteinCellular contentAlzheimer's diseaseNeurodegenerative diseasesProteinB2-adrenoceptorsPulmonary disease