Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability
Zamarbide M, Mossa A, Muñoz-Llancao P, Wilkinson M, Pond H, Oaks A, Manzini M. Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability. Biological Psychiatry 2018, 85: 760-768. PMID: 30732858, PMCID: PMC6474812, DOI: 10.1016/j.biopsych.2018.12.013.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive deficitsIntellectual disabilitySpectrum disorderNeurodevelopmental disordersMouse model of autismFemale miceRegulates cyclic adenosine monophosphateSpatial memory deficitsModel of autismPrevalence of neurodevelopmental disordersMale micePDE4D activityMale-specific mannerMemory deficitsSpatial memoryCyclic adenosine monophosphateIntracellular signalingBehavioral studiesMolecular deficitsAutismBehavioral differencesHippocampusCC2D1ADeficits