2015
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Muñoz-Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc'h F, Schmidt M, González-Billault C. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. Journal Of Neuroscience 2015, 35: 11315-11329. PMID: 26269639, PMCID: PMC6605123, DOI: 10.1523/jneurosci.3645-14.2015.Peer-Reviewed Original ResearchConceptsNeuronal polarityAcquisition of neuronal polarityAxon specificationGenetic manipulationRap1b activationExchange proteinGuanine exchange factorKnock-outEpac signalingRegulate neuronal polarityProtein kinase A.Axon determinationRap GTPasesWild-type neuronsExchange factorActivation of protein kinase A.Polarity defectsMouse neuronsRat hippocampal neuronsMessenger cAMPMolecular eventsEpacMature axonsCAMP-dependent mechanismPharmacological inhibition
2012
The role of small GTPases in neuronal morphogenesis and polarity
Gonzalez‐Billault C, Muñoz‐Llancao P, Henriquez D, Wojnacki J, Conde C, Caceres A. The role of small GTPases in neuronal morphogenesis and polarity. Cytoskeleton 2012, 69: 464-485. PMID: 22605667, DOI: 10.1002/cm.21034.Peer-Reviewed Original ResearchConceptsNeuronal morphogenesisRegulation of cytoskeletal dynamicsParticipation of RhoASmall GTPasesActin cytoskeletonCytoskeletal dynamicsNeuronal polarityDynamic remodelingMorphogenetic eventsGTPaseCross-talkMorphogenesisAxonal elongationFamily membersSynaptic plasticityCdc42CytoskeletonRhoATC10ActinMicrotubulesRacRegulation