Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Muñoz-Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc'h F, Schmidt M, González-Billault C. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. Journal Of Neuroscience 2015, 35: 11315-11329. PMID: 26269639, PMCID: PMC6605123, DOI: 10.1523/jneurosci.3645-14.2015.Peer-Reviewed Original ResearchConceptsNeuronal polarityAcquisition of neuronal polarityAxon specificationGenetic manipulationRap1b activationExchange proteinGuanine exchange factorKnock-outEpac signalingRegulate neuronal polarityProtein kinase A.Axon determinationRap GTPasesWild-type neuronsExchange factorActivation of protein kinase A.Polarity defectsMouse neuronsRat hippocampal neuronsMessenger cAMPMolecular eventsEpacMature axonsCAMP-dependent mechanismPharmacological inhibition