Upregulation of Epac-1 in hepatic stellate cells by Prostaglandin E2 in liver fibrosis is associated with reduced fibrogenesis.
Schippers M, Beljaars L, Post E, Lotersztajn S, Reker-Smit C, Han B, Munoz-Llancao P, Schmidt M, Poelstra K. Upregulation of Epac-1 in hepatic stellate cells by Prostaglandin E2 in liver fibrosis is associated with reduced fibrogenesis. Journal Of Pharmacology And Experimental Therapeutics 2017, 363: jpet.117.241646. PMID: 28864467, DOI: 10.1124/jpet.117.241646.Peer-Reviewed Original ResearchConceptsEpac-1 activationEpac-1Hepatic stellate cellsNiflumic acidPlatelet-derived growth factor-induced proliferationLiver fibrosisFibrotic livers of miceReduced Rho-kinase activityKupffer cellsIsolated hepatic stellate cellsStellate cellsCAMP-mediated effectsGrowth factor-induced proliferationWeeks carbon tetrachlorideEffect of PGE<sub>2</sub> onEPAC-1 expressionKinase activityProtein kinase A expressionRho-kinase activityWestern blot analysisActivity in vitroProstaglandin E<sub>2</sub>Cyclo-oxygenase productsDownstream targetsCell-specific delivery