2022
Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Faustino EVS, Karam O, Parker RI, Hanson SJ, Brandão LR, Monagle P. Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics 2022, 149: s79-s83. PMID: 34970670, DOI: 10.1542/peds.2021-052888l.Peer-Reviewed Original ResearchConceptsCoagulation dysfunctionIll childrenCritical illnessStandard data extraction formOrgan-specific outcomesPediatric critical illnessPODIUM Consensus ConferenceD-dimer valuesInternational normalized ratioPatient-centered outcomesData extraction formOutcomes of interestLiver dysfunctionPlatelet countAdverse outcomesNormalized ratioFunctional statusEligible studiesFibrinogen levelsBias assessmentCoagulation testsCurrent evidenceConsensus conferenceElectronic searchTask force members
2021
Variation in Neonatal Transfusion Practice
Patel RM, Hendrickson JE, Nellis ME, Birch R, Goel R, Karam O, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Sola-Visner M, National Heart L, Mast A, Hod E, Custer B, Vichinsky E, Spencer B, Mathew S, Harris D, Busch M, Norris P, Ness P, Kleinman S, Tamburro R, Glynn S, Malkin K. Variation in Neonatal Transfusion Practice. The Journal Of Pediatrics 2021, 235: 92-99.e4. PMID: 33836184, PMCID: PMC8316298, DOI: 10.1016/j.jpeds.2021.04.002.Peer-Reviewed Original ResearchConceptsWeeks of gestationEntire cohortPretransfusion hemoglobinPlatelet countNeonatal transfusionBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIInternational normalized ratio (INR) valuesHematologic valuesNeonatal transfusion practicesPretransfusion platelet countRetrospective cohort studyBlood product transfusionGestational age groupsPatient blood managementNational Heart LungRecipient EpidemiologyInitial hospitalizationProduct transfusionCohort studyRed blood cellsGestational ageTransfusion practiceHeart LungBlood management
2020
Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood TransfusionChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHemorrhageHumansInfantInfant, NewbornIntensive Care Units, PediatricInternational Normalized RatioMalePlasmaPlatelet CountPlatelet TransfusionPractice Guidelines as TopicProspective StudiesSurveys and QuestionnairesConceptsExtracorporeal membrane oxygenationMembrane oxygenationPlatelet transfusionsTotal platelet countPlasma transfusionPlatelet countSubgroup analysisInstitutional protocolMedian increaseInternational point prevalence studyPediatric extracorporeal membrane oxygenationTotal median doseInternational normalized ratioML/Point prevalence studyPlatelet count valuesScreening weekMedian doseMild coagulopathyNormalized ratioInterventional studyLocal guidelinesObservational studyMedian reductionTransfusion
2019
International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsOncologic diagnosisIll childrenCurrent recommendationsHematopoietic stem cell transplantationCritically Ill ChildrenExtracorporeal life supportStem cell transplantationTotal platelet countMechanical ventilationPlatelet countAppropriate indicationsCell transplantationPediatric intensivistsSubgroup analysisObservational studyPlatelet functionTransfusionParent studyTherapeutic transfusionTotal plateletsLife supportDiagnosisVulnerable populationsSignificant differencesEffects of ABO Matching of Platelet Transfusions in Critically Ill Children*
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children*. Pediatric Critical Care Medicine 2019, 20: e61-e69. PMID: 30422914, PMCID: PMC6709973, DOI: 10.1097/pcc.0000000000001779.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsPlatelet countIll childrenTransfusion reactionsMinor incompatibilityCells/LABO-incompatible platelet transfusionsABO-compatible transfusionsABO-identical transfusionsABO-incompatible plateletsIncompatible platelet transfusionsCritically Ill ChildrenABO-identical plateletsABO-compatible plateletsMajor incompatibilityIncompatible plateletsNonbleeding patientsScreening weekPrimary outcomeSecondary outcomesABO matchingCompatible plateletsTransfusion doseMechanical ventilationOncologic diagnosis
2018
Platelet Transfusion Practices in Critically Ill Children
Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Platelet Transfusion Practices in Critically Ill Children. Critical Care Medicine 2018, 46: 1309-1317. PMID: 29727368, PMCID: PMC6476545, DOI: 10.1097/ccm.0000000000003192.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsCells/LMajor bleedingProphylactic transfusionICU mortalityMinor bleedingIll childrenOverall ICU mortalityPediatric critical illnessPlatelet transfusion practicesProspective cohort studyProphylactic platelet transfusionsCohort studyCritical illnessPost transfusionAdjusted analysisPlatelet countTransfusion practiceAppropriate indicationsMedian changePlatelet doseTransfusionBleedingCells/L.Prophylaxis