2021
Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients
Tarquinio KM, Karsies T, Shein SL, Beardsley A, Khemani R, Schwarz A, Smith L, Flori H, Karam O, Cao Q, Haider Z, Smirnova E, Serrano MG, Buck GA, Willson DF. Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients. Pediatric Pulmonology 2021, 57: 508-518. PMID: 34811963, PMCID: PMC8809006, DOI: 10.1002/ppul.25769.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionDays of intubationAirway microbiomeSerial tracheal aspirate samplesPediatric intensive care unitIntensive care unitIntubated pediatric patientsTracheal aspirate samplesTracheal microbiomePediatric patientsCare unitClinical parametersIntubation periodClinical variablesAntibiotic treatmentVentilated subjectsAspirate samplesInfection scoreMedian numberSubject demographicsPorphyromonadaceae familyMicrobiome patternsIntubationVeillonella atypicaPatientsCompliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*
Karsies T, Tarquinio K, Shein SL, Beardsley AL, Prentice E, Karam O, Fontela P, Moore-Clingenpeel M, Willson DF. Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*. Pediatric Critical Care Medicine 2021, 22: 859-869. PMID: 33965989, DOI: 10.1097/pcc.0000000000002761.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionPositive respiratory culturesRespiratory culturesAntibiotic continuationPhase 3 subjectsRespiratory culture resultsVentilator-Associated InfectionsObservational cohort studyOverall study populationBaseline data collectionPhase 1Antibiotic discontinuationAntibiotic recommendationsAntibiotic guidelinesAntibiotic decisionsCohort studyGuideline adherenceMicrobiologic dataIllness severityMechanical ventilationAntibiotic managementRespiratory secretionsAntibiotic utilizationConsensus guidelinesAntibiotic treatment
2019
Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections.
Shein SL, Karam O, Beardsley A, Karsies T, Prentice E, Tarquinio KM, Willson DF. Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections. Pediatric Critical Care Medicine 2019, 20: 697-706. PMID: 30985606, DOI: 10.1097/pcc.0000000000001942.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionPhase 1 dataAntibiotic guidelinesGuideline scoreAntibiotic usePediatric Logistic Organ Dysfunction-2 scoreDuration of antibioticsPICU-free daysVentilator-Associated InfectionsVentilator-free daysInitiation of antibioticsProspective data collectionPhase 3Median ageMechanical ventilationVentilated childrenScore 3Consensus conferenceClinical testingScoring systemInfectionLiterature searchExpert panelAntibioticsScores