2020
Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children
Nellis ME, Spinella PC, Tucci M, Stanworth SJ, Steiner ME, Cushing MM, Davis PJ, Karam O, The Pediatric Acute Lung Injury and Sepsis Investigators network P. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children. Transfusion 2020, 60: 2849-2858. PMID: 32959409, PMCID: PMC8396066, DOI: 10.1111/trf.16094.Peer-Reviewed Original ResearchConceptsClinical outcomesIll childrenPLT transfusionsObservational point prevalence studyPediatric intensive care unitStorage ageSafety of plateletsFurther prospective evaluationPoint prevalence studyIntensive care unitImmune system dysfunctionFebrile transfusion reactionsDays of ageScreening weekCare unitProspective evaluationSystem dysfunctionTransfusion reactionsPlatelet changesTransfusionPLT countTransfusion efficacyAge groupsSecondary analysisSignificant association
2018
International, multicentre, observational study of fluid bolus therapy in neonates
Keir AK, Karam O, Hodyl N, Stark MJ, Liley HG, Shah PS, Stanworth SJ, Group O. International, multicentre, observational study of fluid bolus therapy in neonates. Journal Of Paediatrics And Child Health 2018, 55: 632-639. PMID: 30328174, DOI: 10.1111/jpc.14260.Peer-Reviewed Original ResearchConceptsFluid bolus therapyBolus therapyNeonatal unitHaemodynamic compromiseObservational studyFluid bolus administrationMulticentre observational studyRisk-benefit profilePooled prevalence rateWide international variationDays of ageClinical improvementFrequent indicationAppropriate indicationsFluid bolusMetabolic acidosisPoor perfusionPatient daysBolus administrationPrevalence ratesStudy daysNeonatesStudy periodTherapyRelevant studies